4.7T 下正常与退行性椎间盘-椎体复合体的三维超短回波时间（3D UTE）磁共振成像：一项具有纵向评估的可行性研究。

Three-dimensional ultrashort echo time (3D UTE) magnetic resonance imaging (MRI) of the normal and degenerative disco-vertebral complex at 4.7 T: a feasibility study with longitudinal evaluation.

机构信息

Department of Radiology, University Hospital of Bordeaux, Bordeaux, France.

Centre de Résonance Magnétique des Systèmes Biologiques, CNRS/University of Bordeaux, Bordeaux, France.

出版信息

Eur Spine J. 2021 May;30(5):1144-1154. doi: 10.1007/s00586-021-06755-x. Epub 2021 Feb 20.

DOI:10.1007/s00586-021-06755-x

PMID:33609189

Abstract

OBJECTIVES

To assess feasibility of a three-dimensional ultrashort echo time (3D-UTE)-sequence to evaluate normal and pathological disco-vertebral complex (DVC), with assessment of its different portions in a rat model of degenerative disk disease (DDD) with histological correlation. To assess whether this sequence, in comparison with long echo time T2-weighted sequence, is able to monitor DDD with differentiation of early from chronic DVC changes in pathological mechanical conditions.

METHODS

Five rats were induced with DDD model by percutaneous disk trituration of the tail with an 18-G needle under US-guidance and imaged at 4.7 T. MRI protocol included fat-saturated-T2 (RARE) and 3D-UTE-sequences performed at baseline (day 0. n = 5 animals /10 DVC) and each week (W) from W1 to W10 postoperatively. Visual analysis and signal intensity measurements of SNR and CNR of all DVC portions were performed on RARE and UTE images. Following killing (baseline, n = 1/2 DVC; W2, n = 2/4 DVC; W10, n = 2/4 DVC), histological analysis was performed and compared with MRI.

RESULTS

In normal DVC, unlike conventional RARE-sequences, 3D-UTE allowed complete identification of DVC zonal anatomy including on visual analysis and CNR measurements. In pathological conditions, SNR and CNR measurements of the annulus fibrosus and nucleus pulposus on 3D-UTE distinguished early discitis at W1 from chronic discopathy (P < 0.001 for SNR and P < 0.001 for CNR). Neither the normal complete anatomy of the DVC nor its pathological patterns could be assessed on conventional sequences.

CONCLUSIONS

Unlike conventional sequences, 3D-UTE enables visualization of the complete normal DVC anatomy and enables monitoring of DDD differentiating between early DVC changes from chronic ones.

LEVEL OF EVIDENCE I

Diagnostic: individual cross-sectional studies with the consistently applied reference standard and blinding.

摘要

目的

评估三维超短回波时间（3D-UTE）序列评估正常和病理性椎间盘-椎体复合体（DVC）的可行性，并在退行性椎间盘疾病（DDD）大鼠模型中进行组织学相关性评估其不同部位。评估该序列与长回波时间 T2 加权序列相比，是否能够在病理性机械条件下，从慢性 DVC 变化中区分早期 DDD。

方法

通过超声引导下的 18-G 针经皮椎间盘研磨在 5 只大鼠中诱导 DDD 模型，并在 4.7T 下进行 MRI 检查。MRI 方案包括脂肪饱和 T2（RARE）和 3D-UTE 序列，在基线（第 0 天，n=5 只动物/10 个 DVC）和术后每周（W1 至 W10）进行。在 RARE 和 UTE 图像上对所有 DVC 部位的 SNR 和 CNR 的信号强度进行视觉分析和测量。处死（基线，n=1/2 DVC；W2，n=2/4 DVC；W10，n=2/4 DVC）后，进行组织学分析，并与 MRI 进行比较。

结果

在正常 DVC 中，与传统的 RARE 序列不同，3D-UTE 允许完整识别 DVC 分区解剖结构，包括在视觉分析和 CNR 测量中。在病理性条件下，3D-UTE 测量的纤维环和髓核的 SNR 和 CNR 可区分 W1 时的早期椎间盘炎与慢性椎间盘病（SNR 差异有统计学意义 P<0.001，CNR 差异有统计学意义 P<0.001）。常规序列既不能评估 DVC 的正常完整解剖结构，也不能评估其病理模式。