Dermatology Department, Rasool Akram Medical Complex, Iran University of Medical Sciences (IUMS), Tehran, Iran.
Iran University of Medical Sciences (IUMS), Tehran, Iran.
J Cosmet Dermatol. 2021 Nov;20(11):3656-3660. doi: 10.1111/jocd.14014. Epub 2021 Mar 2.
There are pieces of evidence regarding the association between melasma and metabolic syndrome. To assess the prevalence and grade of nonalcoholic fatty liver and lipid profile status in patients with melasma, we designed this case-control study.
This study was performed on 30 consecutive women with melasma who referred to the dermatology clinic of the hospital as the case group and 34 healthy women. For all participants, serum lipid profiles and liver enzymes were checked. Also, the existence of fatty liver was assessed by ultrasonography.
Except for serum level of LDL (low-density lipoprotein) that was significantly higher in the melasma group than in the healthy group (104.23 ± 25.00 mg/dl versus 89.85 ± 23.00 mg/dl, p = 0.020), the level of other parameters including other lipid profiles, blood sugar, or liver enzymes was similar in both groups. In ultrasonography, the overall prevalence of fatty liver was 23.3% in the melasma group and 20.6% in the control group, and no difference was found between the two groups in grade of fatty liver (p = 0.791).
The study showed a higher serum LDL level in patients with melasma compared to women without melasma, but there was no difference between the groups in prevalence or grade of fatty liver.
有一些证据表明黄褐斑与代谢综合征之间存在关联。为了评估黄褐斑患者中非酒精性脂肪肝的患病率和严重程度以及血脂谱状况，我们设计了这项病例对照研究。
本研究纳入了 30 名连续就诊于医院皮肤科的黄褐斑女性患者作为病例组，以及 34 名健康女性作为对照组。所有参与者的血脂谱和肝酶均进行了检查。此外，还通过超声检查评估了脂肪肝的存在。
除了黄褐斑组的血清 LDL（低密度脂蛋白）水平明显高于对照组（104.23±25.00mg/dl 与 89.85±23.00mg/dl，p=0.020）外，两组的其他参数水平，包括其他血脂谱、血糖或肝酶，均相似。在超声检查中，黄褐斑组脂肪肝的总体患病率为 23.3%，对照组为 20.6%，两组脂肪肝的严重程度无差异（p=0.791）。
本研究显示，与无黄褐斑的女性相比，黄褐斑患者的血清 LDL 水平更高，但两组在脂肪肝的患病率或严重程度方面无差异。
