男性睾酮水平与黄褐斑的相关性：印度尼西亚的一项病例对照研究。
Association of testosterone level with melasma in men: a case-control study in Indonesia.
机构信息
Department of Dermatology and Venereology, Faculty of Medicine Udayana University, Ngoerah General Hospital, Denpasar, Bali, Indonesia.
出版信息
Pan Afr Med J. 2022 Dec 16;43:194. doi: 10.11604/pamj.2022.43.194.37435. eCollection 2022.
INTRODUCTION
melasma is a common acquired hypermelanosis which occurs mostly in face that caused by many factors. One of the pathogenesis of melasma in men is affected by testosterone. This study aimed to investigate the relationship between testosterone levels and melasma in men and its association with the severity of melasma as measured by the melasma area and severity index (MASI) score.
METHODS
a case-control study involving 30 subjects with melasma and 30 subjects without melasma who were treated at the outpatient clinic of Dermatovenereology of Ngoerah General Hospital from June to August 2022. Descriptive statistical analysis is to determine frequencies and percentages. Bivariate analysis was used to find any risk factor between testosterone level and melasma. Data obtained from the two groups then analyzed for correlation between the MASI score and testosterone levels.
RESULTS
mean age of the subjects in the melasma group was 43.83±6.30 and in control group was 43.80±6.09. Mean testosterone level in the melasma group (7.55±1.77) was significantly lower than the control group (21.07±6.65; p = 0.001). Subject with testosterone level ≥8.92 nmol/L has 6.9 times risk of melasma compare to control (aOR: 6.986, 95% CI 1.905-25.622; p = 0.003).
CONCLUSION
low testosterone levels possibly have a role in pathogenesis of melasma in men.
简介
黄褐斑是一种常见的获得性色素沉着过度，主要发生在面部，由多种因素引起。男性黄褐斑的发病机制之一是受睾酮的影响。本研究旨在探讨男性睾酮水平与黄褐斑的关系及其与黄褐斑面积和严重程度指数（MASI）评分所衡量的黄褐斑严重程度的相关性。
方法
一项病例对照研究，纳入了 2022 年 6 月至 8 月在 Ngoerah 综合医院皮肤科门诊就诊的 30 例黄褐斑患者和 30 例非黄褐斑患者。采用描述性统计分析确定频率和百分比。采用双变量分析来寻找睾酮水平与黄褐斑之间的任何危险因素。然后对两组数据进行分析，以确定 MASI 评分与睾酮水平之间的相关性。
结果
黄褐斑组的平均年龄为 43.83±6.30 岁，对照组为 43.80±6.09 岁。黄褐斑组的平均睾酮水平（7.55±1.77）明显低于对照组（21.07±6.65；p=0.001）。睾酮水平≥8.92 nmol/L 的患者患黄褐斑的风险是对照组的 6.9 倍（aOR：6.986，95%CI 1.905-25.622；p=0.003）。
结论
低睾酮水平可能在男性黄褐斑的发病机制中起作用。
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