Department of Gynecology, Baodi District People's Hospital, Tianjin, 301800, China.
Department of Women's Insurance Guidance, Women's And Children's Health Center, Tianjin, 300070, Chin.
Acta Biochim Pol. 2021 Feb 20;68(1):49-53. doi: 10.18388/abp.2020_5379.
Human papillomavirus (HPV) is the primary causative agent for the uterine cervical cancer. The expression of oncoproteins E6/E7 promotes apoptosis inhibition and increases the risk of cervical cancer progression. Some research reported that elevated expression of paxillin (PXN) stimulated cancer growth and invasion. However, the clinical significance of PXN in cervical cancer has not been well characterized so far. We found that PXN mRNA expression and protein level are significantly upregulated in cervical cancer cells compared to adjacent normal cells. Furthermore, the paxillin over-expression was correlated with potential of tumorigenesis and invasion. Cervical cancer cells with increased paxillin expression had an ability to form more tumor clones and were characterized by higher invasiveness as well. Therefore, our findings suggest that paxillin may act as an important prognostic factor for cervical cancer patients as it promotes tumor regeneration and invasion.
人乳头瘤病毒（HPV）是子宫颈癌的主要致病因子。癌蛋白 E6/E7 的表达促进细胞凋亡抑制，增加宫颈癌进展的风险。一些研究报道，整联蛋白连接激酶（paxillin，PXN）的高表达刺激癌症的生长和侵袭。然而，PXN 在宫颈癌中的临床意义尚未得到很好的描述。我们发现，与相邻的正常细胞相比，宫颈癌细胞中 PXN mRNA 表达和蛋白水平显著上调。此外，paxillin 的过表达与肿瘤发生和侵袭的潜能相关。paxillin 表达增加的宫颈癌细胞具有形成更多肿瘤克隆的能力，并且侵袭性也更高。因此，我们的研究结果表明，paxillin 可能作为宫颈癌患者的一个重要预后因素，因为它促进肿瘤的再生和侵袭。
