Institute of Molecular Science, Chemical Biology and Molecular Engineering Laboratory of Education Ministry, Shanxi University, Taiyuan, Shanxi, 030006, China.
School of Chemical Engineering, Beijing Institute of Petrochemical Technology, Beijing, 102617, China.
Photodiagnosis Photodyn Ther. 2021 Jun;34:102223. doi: 10.1016/j.pdpdt.2021.102223. Epub 2021 Feb 17.
The photodamage induced by PDT usually occurs at the site where the photosensitizers accumulate in the tumor cells, thus the modulation of intrinsic apoptosis by mitochondria-targeting PDT drugs might be a promising way to enhance the therapeutic efficacy of PDT drugs against tumor cells. Novel triphenylphosphonium-functionalized nanocomposites employed as carriers of a photoactive platinum diimine complex have been fabricated and characterized. Upon irradiation, the IC value of photosensitizer-loaded triphenylphosphonium-functionalized nanocomposites was found to be 17.4 or 14.4 times lower than that of the photosensitizer studied alone against HCT116 cells or A549 cells, respectively. The results suggested that the triphenylphosphonium- functionalized nanocomposites as drug delivery vehicles could significantly enhance the photodynamic efficacy of the photosensitizer.
PDT 诱导的光损伤通常发生在光敏剂在肿瘤细胞中积累的部位，因此，通过靶向线粒体的 PDT 药物来调节内在凋亡可能是增强 PDT 药物对肿瘤细胞治疗效果的一种有前途的方法。已经制备和表征了新型三苯基膦功能化纳米复合材料，用作光活性铂二亚胺配合物的载体。照射后，负载光敏剂的三苯基膦功能化纳米复合材料的 IC 值比单独研究的光敏剂对 HCT116 细胞或 A549 细胞的 IC 值分别低 17.4 或 14.4 倍。结果表明，三苯基膦功能化纳米复合材料作为药物递送载体可以显著提高光敏剂的光动力疗效。
