Zhang Zhigang, Li Haisha, Dai Ruihui, Chai Aiyun
Chemical Biology and Molecular Engineering Laboratory of Education Ministry, Institute of Molecular Science, Shanxi University, Taiyuan, 030006, Shanxi, China.
Biometals. 2015 Oct;28(5):945-50. doi: 10.1007/s10534-015-9878-0. Epub 2015 Aug 28.
Tartaric acid-modified core-shell magnetite-silica nanocomposites were prepared by a sol-gel method, and characterized by X-ray diffraction, Fourier transform infrared spectroscopy, transmission electron microscopy and dynamic light scattering. Then the nanocomposites were employed as carriers of a photoactive platinum diimine complex. Photoinduced cytotoxicity by the photosensitizer-loaded nanocomposites in different human carcinoma cells has been studied by cell viability assay. The results suggest that the as-synthesized nanocomposites have good stability in water, and the cytotoxicity induced by the platinum diimine complex in red light can be significantly enhanced when the photosensitizer is loaded with the magnetic nanocomposites.
采用溶胶-凝胶法制备了酒石酸改性的核壳型磁铁矿-二氧化硅纳米复合材料，并通过X射线衍射、傅里叶变换红外光谱、透射电子显微镜和动态光散射对其进行了表征。然后将该纳米复合材料用作光活性铂二亚胺配合物的载体。通过细胞活力测定研究了负载光敏剂的纳米复合材料在不同人类癌细胞中的光诱导细胞毒性。结果表明，所合成的纳米复合材料在水中具有良好的稳定性，当光敏剂负载在磁性纳米复合材料上时，铂二亚胺配合物在红光下诱导的细胞毒性可显著增强。
