Key Lab of Medical Protection for Electromagnetic Radiation, Ministry of Education of China, Institute of Toxicology, College of Preventive Medicine, Army Medical University (Third Military Medical University), Chongqing, China; Department of Toxicology, School of Public Health, Guizhou Medical University, Guiyang, Guizhou, China.
Key Lab of Medical Protection for Electromagnetic Radiation, Ministry of Education of China, Institute of Toxicology, College of Preventive Medicine, Army Medical University (Third Military Medical University), Chongqing, China.
Sci Total Environ. 2021 Jun 20;774:145691. doi: 10.1016/j.scitotenv.2021.145691. Epub 2021 Feb 6.
Air pollution, which is associated with male reproductive health. However, it is unknown the acute effects of ambient air pollutants exposure on male reproductive hormones. The current study, we measured serum levels of reproductive hormone in 2030 blood samples gathered from The Male Reproductive Health in Chongqing College Students (MARHCS) cohort study. We derived a full coverage of ambient air pollutant (PM, PM, SO, NO, CO and O) concentrations by employing machine learning algorithms, and used a mixed-effect model to estimate single-day and cumulative effects of air pollutants exposure on serum reproductive hormones. Our results showed that (1) PM and PM concentrations were positively associated with estradiol (E) in both single and cumulative lag days, but were negatively associated with the ratio of Testosterone/E (the T/E ratio). NO was positively associated with estradiol at lag day 2 (95% CI: 0.290, 0.881; corrected P = 0.048) and lag 0-2 days (95% CI: 0.523, 1.337; corrected P = 0.003), with progesterone (P) at lag day 2 and lag day 3 (corrected P < 0.05). There was also a positive association between CO exposure and progesterone at lag day 2. (2) SO was inversely associated with E at lag day 3, 4 and lag 0-4 days, and progesterone at lag day 0, 1, 2 and lag 0-1, 0-2, 0-4 days, but positively associated with the T/E ratio at lag day 3, 4 and lag 0-4 days (corrected P < 0.05). O exposure was negatively associated with E at lag day 3 (95% CI: -0.216, -0.074, corrected P = 0.03). (3) No significant associations were found between the cumulative daily average air pollutant exposure of CO, O and hormone outcomes. This study suggests that short-term exposure to air pollutants may thus alter reproductive hormone levels, especially on serum estradiol, progesterone levels and the T/E ratio.
空气污染与男性生殖健康有关。然而，目前尚不清楚环境空气污染物暴露对男性生殖激素的急性影响。在本研究中，我们测量了来自重庆大学生男性生殖健康（MARHCS）队列研究的 2030 份血样中的生殖激素水平。我们通过机器学习算法得出了大气污染物（PM、PM、SO、NO、CO 和 O）浓度的完整覆盖范围，并使用混合效应模型估计了污染物暴露对血清生殖激素的单日和累积效应。我们的结果表明：（1）PM 和 PM 浓度与雌二醇（E）在单日和累积滞后日均呈正相关，但与睾酮/雌二醇（T/E 比）呈负相关。NO 与雌二醇在滞后 2 天（95%CI：0.290，0.881；校正后 P=0.048）和滞后 0-2 天（95%CI：0.523，1.337；校正后 P=0.003）呈正相关，与孕酮（P）在滞后 2 天和滞后 3 天（校正后 P<0.05）呈正相关。CO 暴露与孕酮在滞后 2 天也呈正相关。（2）SO 在滞后 3、4 天和滞后 0-4 天与 E 呈负相关，在滞后 0、1、2 天和滞后 0-1、0-2、0-4 天与 P 呈负相关，但与滞后 3、4 天和滞后 0-4 天的 T/E 比呈正相关（校正后 P<0.05）。O 暴露与滞后 3 天的 E 呈负相关（95%CI：-0.216，-0.074，校正后 P=0.03）。（3）CO、O 与激素结果的累积日平均空气污染物暴露之间没有显著关联。本研究表明，短期暴露于空气污染物可能会改变生殖激素水平，特别是血清雌二醇、孕酮水平和 T/E 比。
