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Lipoprotein(a) reduction with proprotein convertase subtilisin/kexin type 9 inhibitors: An unsolved mystery.

作者信息

Liberopoulos Evangelos

机构信息

Department of Medicine, University of Ioannina, Greece.

出版信息

Eur J Prev Cardiol. 2021 Jul 23;28(8):813-815. doi: 10.1177/2047487320926777.

DOI:10.1177/2047487320926777
PMID:33611488
Abstract
摘要

相似文献

1
Lipoprotein(a) reduction with proprotein convertase subtilisin/kexin type 9 inhibitors: An unsolved mystery.前蛋白转化酶枯草溶菌素/克新9型抑制剂降低脂蛋白(a)：一个未解之谜。
Eur J Prev Cardiol. 2021 Jul 23;28(8):813-815. doi: 10.1177/2047487320926777.
2
From lipoprotein apheresis to proprotein convertase subtilisin/kexin type 9 inhibitors: Impact on low-density lipoprotein cholesterol and C-reactive protein levels in cardiovascular disease patients.从脂蛋白吸附术到前蛋白转化酶枯草溶菌素 9 抑制剂：对心血管疾病患者的低密度脂蛋白胆固醇和 C 反应蛋白水平的影响。
Eur J Prev Cardiol. 2018 Nov;25(17):1843-1851. doi: 10.1177/2047487318792626. Epub 2018 Jul 30.
3
Proprotein Convertase Subtilisin/Kexin Type 9 Loss-of-Function Is Detrimental to the Juvenile Host With Septic Shock.丝氨酸蛋白酶原 9 型缺陷型失活对幼年脓毒性休克宿主有害。
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Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors: A Brief Overview.前蛋白转化酶枯草杆菌蛋白酶/克新9型抑制剂：简要概述
Am J Med. 2017 Feb;130(2):229.e1-229.e4. doi: 10.1016/j.amjmed.2016.09.021. Epub 2016 Oct 15.
5
Injection of an improperly stored proprotein convertase subtilisin/kexin type 9 monoclonal antibody in a patient with secondary dyslipidemia from nephrotic syndrome: a case report.注射储存不当的前蛋白转化酶枯草溶菌素 9 单克隆抗体导致肾病综合征继发血脂异常患者：病例报告。
J Med Case Rep. 2023 Mar 11;17(1):89. doi: 10.1186/s13256-023-03804-5.
6
Long-term exposure to air pollution raises circulating levels of proprotein convertase subtilisin/kexin type 9 in obese individuals.长期暴露于空气污染会增加肥胖个体中蛋白水解酶枯草溶菌素/克胰蛋白酶 9 的循环水平。
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7
Plasma proprotein convertase subtilisin/kexin type 9 concentration and recurrent cardiovascular events in patients with familial hypercholesterolemia.家族性高胆固醇血症患者的血浆前蛋白转化酶枯草溶菌素/凝血酶 9 浓度与复发性心血管事件。
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Low Low-Density Lipoprotein Levels Are Associated With, But Do Not Causally Contribute to, Increased Mortality in Sepsis.低低密度脂蛋白水平与败血症死亡率增加相关，但不会引起死亡率增加。
Crit Care Med. 2019 Mar;47(3):463-466. doi: 10.1097/CCM.0000000000003551.
9
AMG145, a monoclonal antibody against proprotein convertase subtilisin kexin type 9, significantly reduces lipoprotein(a) in hypercholesterolemic patients receiving statin therapy: an analysis from the LDL-C Assessment with Proprotein Convertase Subtilisin Kexin Type 9 Monoclonal Antibody Inhibition Combined with Statin Therapy (LAPLACE)-Thrombolysis in Myocardial Infarction (TIMI) 57 trial.AMG145，一种针对前蛋白转化酶枯草溶菌素 9 的单克隆抗体，可显著降低接受他汀类药物治疗的高胆固醇血症患者的脂蛋白(a)：来自 LDL-C 评估与前蛋白转化酶枯草溶菌素 9 单克隆抗体抑制联合他汀类药物治疗（LAPLACE）-心肌梗死溶栓治疗（TIMI）57 试验的分析。
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10
Cyclase-associated protein 1 is a binding partner of proprotein convertase subtilisin/kexin type-9 and is required for the degradation of low-density lipoprotein receptors by proprotein convertase subtilisin/kexin type-9.衔接蛋白 1 是蛋白水解酶原转化酶枯草溶菌素/柯萨奇蛋白酶 9 的结合伴侣，并且对于蛋白水解酶原转化酶枯草溶菌素/柯萨奇蛋白酶 9 降解低密度脂蛋白受体是必需的。
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引用本文的文献

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The efficacy and safety of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors combined with statins in patients with hypercholesterolemia: a network meta-analysis.前蛋白转化酶枯草溶菌素9型（PCSK9）抑制剂联合他汀类药物治疗高胆固醇血症患者的疗效和安全性：一项网状Meta分析。
Front Cardiovasc Med. 2024 Sep 25;11:1454918. doi: 10.3389/fcvm.2024.1454918. eCollection 2024.
2
Lipoprotein(a) and Low-Molecular-Weight Apo(a) Phenotype as Determinants of New Cardiovascular Events in Patients with Premature Coronary Heart Disease.脂蛋白(a)与低分子量载脂蛋白(a)表型作为早发冠心病患者新发心血管事件的决定因素
Diseases. 2023 Oct 18;11(4):145. doi: 10.3390/diseases11040145.
3
Effects of Lipid-Modifying and Other Drugs on Lipoprotein(a) Levels-Potent Clinical Implications.
调脂药物及其他药物对脂蛋白(a)水平的影响——重大临床意义
Pharmaceuticals (Basel). 2023 May 16;16(5):750. doi: 10.3390/ph16050750.
4
Familial Hypercholesterolemia and Lipoprotein(a): A Gordian Knot in Cardiovascular Prevention.家族性高胆固醇血症与脂蛋白(a)：心血管疾病预防中的一个难题。
Metabolites. 2022 Nov 4;12(11):1065. doi: 10.3390/metabo12111065.
5
Association between PCSK9 Levels and Markers of Inflammation, Oxidative Stress, and Endothelial Dysfunction in a Population of Nondialysis Chronic Kidney Disease Patients.载脂蛋白 B 代谢关键酶 9 水平与非透析慢性肾脏病患者炎症、氧化应激和内皮功能障碍标志物的相关性。
Oxid Med Cell Longev. 2021 Jul 20;2021:6677012. doi: 10.1155/2021/6677012. eCollection 2021.
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Lipoprotein(a) Lowering-From Lipoprotein Apheresis to Antisense Oligonucleotide Approach.降低脂蛋白(a)——从脂蛋白分离术到反义寡核苷酸疗法
J Clin Med. 2020 Jul 3;9(7):2103. doi: 10.3390/jcm9072103.
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Achieving low-density lipoprotein cholesterol targets as assessed by different methods in patients with familial hypercholesterolemia: an analysis from the HELLAS-FH registry.不同方法评估的家族性高胆固醇血症患者的低密度脂蛋白胆固醇目标达标情况：来自 HELLAS-FH 登记研究的分析。
Lipids Health Dis. 2020 May 28;19(1):114. doi: 10.1186/s12944-020-01289-5.