Rao P J, Bhattacharya S K
Department of Pharmacology, Banaras Hindu University, Varanasi, India.
Int J Hyperthermia. 1988 Mar-Apr;4(2):183-9. doi: 10.3109/02656738809029308.
Intracerebroventricularly administered bradykinin (2.5, 5 and 10 micrograms/rat) produced a dose-related increase in the rectal temperature of adult Wistar strain albino rats. The bradykinin-induced hyperthermia was significantly attenuated following pretreatment of the animals with pharmacological agents which selectively reduce rat brain serotonin or prostaglandin (PG) activity. These findings, and those of earlier reports emanating from this laboratory which indicate that centrally administered bradykinin augments rat brain serotonin and PGE2 activity, suggest the involvement of PGs and serotonin in the hyperthermic action of bradykinin in this species.
脑室内注射缓激肽（2.5、5和10微克/大鼠）可使成年Wistar品系白化大鼠的直肠温度呈剂量依赖性升高。在用选择性降低大鼠脑血清素或前列腺素（PG）活性的药物预处理动物后，缓激肽诱导的体温过高明显减弱。这些发现，以及本实验室早期报告的结果表明，中枢给予缓激肽可增强大鼠脑血清素和PGE2活性，提示PGs和血清素参与了该物种中缓激肽的体温过高作用。
