Bhattacharya S K, Mohan Rao P J, Das N, Das Gupta G
Department of Pharmacology, Banaras Hindu University, Varanasi, India.
J Pharm Pharmacol. 1988 May;40(5):367-9. doi: 10.1111/j.2042-7158.1988.tb05270.x.
Intracerebroventricular (i.c.v.) administered bradykinin (2.5 and 5.0 micrograms/rat) was found to augment carrageenan-induced acute paw oedema throughout the 4 h post-carrageenan observation period. The effect was statistically significant with the higher dose. The pro-inflammatory effect of i.c.v. bradykinin was antagonized following pretreatment with hemicholinium and atropine ethoiodide administered i.c.v., drugs that reduce central cholinergic activity. Similarly, central administration of drugs that inhibit the synthesis of eicosanoids, hydrocortisone, diclofenac and paracetamol, also attenuated the pro-inflammatory effect of bradykinin. The findings indicate that the inflammation-promoting effect of centrally administered bradykinin involves the central prostaglandin and cholinergic neurotransmitter systems.
发现在角叉菜胶诱导的急性爪肿胀整个观察期（4小时）内，脑室内（i.c.v.）给予缓激肽（2.5微克/大鼠和5.0微克/大鼠）会增强其肿胀程度。较高剂量时该作用具有统计学意义。预先经脑室内给予半胆碱和乙基碘化阿托品（可降低中枢胆碱能活性的药物）后，脑室内缓激肽的促炎作用受到拮抗。同样，中枢给予抑制类二十烷酸合成的药物（氢化可的松、双氯芬酸和对乙酰氨基酚）也减弱了缓激肽的促炎作用。这些发现表明，中枢给予缓激肽的促炎作用涉及中枢前列腺素和胆碱能神经递质系统。
