Jangjo-Borazjani Soheila, Dastgheib Maryam, Kiyamarsi Efat, Jamshidi Roghayeh, Rahmati-Ahmadabad Saleh, Helalizadeh Masoumeh, Iraji Roya, Cornish Stephen M, Mohammadi-Darestani Shiva, Khojasteh Zohreh, Azarbayjani Mohammad Ali
Department of Physical Education and Sport Sciences, Bushehr Branch, Islamic Azad University, Bushehr, Iran.
Department of Physical Education, Pardis Branch, Islamic Azad University, Pardis, Iran.
Arch Physiol Biochem. 2023 Dec;129(4):913-921. doi: 10.1080/13813455.2021.1886117. Epub 2021 Feb 21.
CONTEXT: Proper nutrition and exercise are effective strategies to improve overall metabolic health in diabetic patients. OBJECTIVE: This study evaluated the effects of Nigella sativa (NS) supplementation during resistance training (RT) on some biochemical variables in type 2 diabetes patients. METHODS: Forty patients were assigned to groups: RT + NS (RN), NS, RT + placebo (RP), and control (CO). RT was performed and NS was consumed for 8 weeks. Blood samples were collected at rest immediately before and after the 8 week intervention. RESULTS: RT or NS by themselves reduced HOMA-IR, insulin, glucose, TG, TC, LDL, ESR, CRP, AST, ALT and ALP, and increased HDL and HOMA-S. The combination of RT and NS, rather than each intervention alone, had significant effects on reduction of HOMA-IR, insulin, ESR and CRP as well as increases in HDL, HOMA-β/S. CONCLUSION: RT combined with NS is sometimes a better strategy compared to single interventions for improving diabetes related biomarkers in type 2 diabetic patients.
背景：适当的营养和运动是改善糖尿病患者整体代谢健康的有效策略。 目的：本研究评估了在抗阻训练（RT）期间补充黑种草（NS）对2型糖尿病患者某些生化指标的影响。 方法：将40名患者分为四组：RT + NS（RN）组、NS组、RT + 安慰剂（RP）组和对照组（CO）。进行抗阻训练并服用NS 8周。在8周干预前后静息状态下采集血样。 结果：单独进行抗阻训练或补充NS均可降低稳态模型评估的胰岛素抵抗（HOMA-IR）、胰岛素、血糖、甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白（LDL）、红细胞沉降率（ESR）、C反应蛋白（CRP）、天门冬氨酸氨基转移酶（AST）、丙氨酸氨基转移酶（ALT）和碱性磷酸酶（ALP），并提高高密度脂蛋白（HDL）和稳态模型评估的β细胞功能（HOMA-S）。与单独的每种干预措施相比，抗阻训练与NS联合使用对降低HOMA-IR、胰岛素、ESR和CRP以及提高HDL、HOMA-β/S具有显著效果。 结论：与单一干预措施相比，抗阻训练与NS联合使用有时是改善2型糖尿病患者糖尿病相关生物标志物的更好策略。
Curr Issues Mol Biol. 2023-4-3
Int J Mol Sci. 2022-10-11
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