Najm Saima, Naureen Humaira, Sultana Kishwar, Anwar Fareeha, Rehman Sarah, Arshad Shumaila, Khan Muhammad Mubbashir
Faculty of Pharmaceutical Sciences, Riphah Institute of Pharmaceutical Sciences, Islamabad, Pakistan / Faculty of Pharmacy, The University of Lahore, Lahore, Pakistan.
Faculty of Pharmaceutical Sciences, Riphah Institute of Pharmaceutical Sciences, Islamabad, Pakistan.
Pak J Pharm Sci. 2020 Jul;33(4(Supplementary)):1779-1786.
Epilepsy is the disease associated with seizures and convulsions. Various antiepileptic drugs have been used widely to treat these disorders. Lamotrigine [6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine] shows certain adverse effects at small doses, to evaluate its efficacy lamotrigine schiff based metal complexes were screened in-silico at voltage gated sodium channel for antiepileptic effect and dihydrofolate reductase enzyme for anticancer activity. Post docking analysis revealed that lamotrigine shows greater antiepileptic effect with its Schiff base complex of tin, with greater binding affinities on voltage gated sodium channel. However, anticancer effect of lamotrigine with its Schiff base silver complex shows highest binding affinity on dihydrofolate reductase enzyme. Study concluded that Schiff base derivative and its metal complexes express significant binding interactions with voltage gated sodium channel and dihydrofolate reductase enzyme.
癫痫是一种与癫痫发作和惊厥相关的疾病。各种抗癫痫药物已被广泛用于治疗这些疾病。拉莫三嗪[6-(2,3-二氯苯基)-1,2,4-三嗪-3,5-二胺]在小剂量时会表现出某些不良反应，为了评估其疗效，基于席夫碱的拉莫三嗪金属配合物在电压门控钠通道上进行了计算机模拟筛选以评估其抗癫痫作用，并在二氢叶酸还原酶上评估其抗癌活性。对接后分析表明，拉莫三嗪与其锡席夫碱配合物显示出更大的抗癫痫作用，对电压门控钠通道具有更高的结合亲和力。然而，拉莫三嗪与其席夫碱银配合物的抗癌作用在二氢叶酸还原酶上显示出最高的结合亲和力。研究得出结论，席夫碱衍生物及其金属配合物与电压门控钠通道和二氢叶酸还原酶表现出显著的结合相互作用。
