Susanti Lina, Kang Seonmi, Lee Eunji, Jeong Dajeong, Jeong Youngseok, Park Sanghyun, Seo Kangmoon
Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, 08826, Korea.
J Vet Med Sci. 2021 Apr 3;83(3):501-506. doi: 10.1292/jvms.20-0668. Epub 2021 Feb 22.
This study was conducted to investigate the efficacy of rocuronium bromide as mydriatic agent in domestic pigeons (Columba livia). This study was done in two phases. In the first phase, rocuronium bromide (0.20 mg/20 µl) was topically instilled to the right eye (OD) of eight domestic pigeons. Pupil diameter was measured before instillation (T0), and at 5 (T05) and 10 (T10) min after instillation, and every 10 min thereafter until 160 (T160) min. Pupillary light reflex (PLR) was assessed using a scoring system at the same time points. In the second phase, the same dosage was instilled twice in the span of 10 min into both eyes (OU) of four pigeons (eight eyes). Measurements were done accordingly. The iris color in the first phase were: gravel, pearl and bull eye. All irises in the second phase were bull eye. Mydriasis were observed in 6/8 (75%) pigeons in the first phase. Maximal mydriasis was observed at T30 (mean pupil diameter=4.62 ± 0.13 mm). Pupil diameter in the treated eye was significantly different from contralateral eye and from T0 since T05 (P=0.017 and P=0.006, respectively)-T120 (P=0.043 and P=0.044, respectively). PLR was disappeared from T10 (P=0.034) to T90 (P=0.041). In the second phase, mydriasis was only observed in 2/8 eyes. This study suggested that rocuronium bromide was able to produce mydriasis in pigeons other than bull eye iris.
本研究旨在探讨罗库溴铵作为家鸽（Columba livia）散瞳剂的疗效。本研究分两个阶段进行。在第一阶段，将罗库溴铵（0.20 mg/20 µl）局部滴入8只家鸽的右眼（OD）。在滴入前（T0）、滴入后5分钟（T05）和10分钟（T10）以及此后每10分钟直至160分钟（T160）测量瞳孔直径。在相同时间点使用评分系统评估瞳孔对光反射（PLR）。在第二阶段，在10分钟内将相同剂量分两次滴入4只鸽子（8只眼）的双眼（OU）。相应地进行测量。第一阶段的虹膜颜色为：砾石色、珍珠色和牛眼。第二阶段的所有虹膜均为牛眼。在第一阶段，6/8（75%）的鸽子出现散瞳。在T30时观察到最大散瞳（平均瞳孔直径 = 4.62 ± 0.13 mm）。自T05（分别为P = 0.017和P = 0.006）至T120（分别为P = 0.043和P = 0.044），治疗眼的瞳孔直径与对侧眼和T0时相比有显著差异。PLR从T10（P = 0.034）至T90（P = 0.041）消失。在第二阶段，仅在2/8只眼中观察到散瞳。本研究表明，罗库溴铵能够使除牛眼虹膜外的鸽子产生散瞳。
