Laboratory of Wildlife Medicine, College of Veterinary Medicine, Jeonbuk National University, Iksan 54596, Korea.
Jeonbuk Wildlife Center, Jeonbuk National University, Iksan 54596, Korea.
J Vet Sci. 2023 Jul;24(4):e59. doi: 10.4142/jvs.23002.
Rocuronium bromide has been evaluated as a mydriatic agent in birds, but the species applied were limited and the dose and effect were variable.
This study aims to evaluate the efficacy of topical rocuronium bromide as mydriatics in 4 species according to horizontal palpebral fissure length: Feral pigeon (), Common kestrel (), Northern boobook (), and Eurasian eagle owl ().
A total of 32 birds (8 for each species) were included as pre-releasing examination. Rocuronium bromide was instilled in one randomly selected eye of each bird based on palpebral fissure length criteria (0.5 mg/50 µL for pigeons, 1 mg/100 µL for kestrels and boobook owls, and 2 mg/200 µL for eagle owls). The contralateral eye was used as control and treated with normal saline. After instillation of the drug, pupil diameter, pupillary light reflex, intraocular pressure, heart rate, and respiratory rate were evaluated at 10 min intervals up to 180 min and at 30 min intervals up to 360 min.
Statistically significant mydriasis was obtained in all birds ( < 0.001). However, in boobook and eagle owls, marked mydriasis persisted until 360 min. Side effects including corneal erosion and lower eyelid paralysis were common, which was observed in 26/32 birds. Blepharospasm was also noted during this study. No systemic adverse signs were observed.
Rocuronium bromide could be a good mydriatics option for 4 species of birds, however, further studies are needed to find lowest effective dose to reduce drug-related side effects.
罗库溴铵已被评估为鸟类的扩瞳剂，但应用的物种有限，剂量和效果也各不相同。
本研究旨在根据水平睑裂长度评估罗库溴铵在 4 种鸟类中的扩瞳效果：野鸽（）、普通红隼（）、北方笑鸮（）和欧亚雕鸮（）。
共纳入 32 只鸟类（每种 8 只）作为释放前检查。根据睑裂长度标准（鸽用 0.5mg/50μL，红隼和笑鸮用 1mg/100μL，雕鸮用 2mg/200μL）将罗库溴铵滴入每只鸟的一只随机选择的眼睛中。对侧眼睛作为对照，并用生理盐水处理。滴药后，在 10 分钟间隔至 180 分钟，以及 30 分钟间隔至 360 分钟时评估瞳孔直径、瞳孔光反射、眼内压、心率和呼吸率。
所有鸟类均出现统计学显著的扩瞳（<0.001）。然而，在笑鸮和雕鸮中，明显的扩瞳持续至 360 分钟。副作用包括角膜侵蚀和下眼睑麻痹很常见，32 只鸟中有 26 只出现这种情况。在研究过程中还注意到了睑痉挛。未观察到全身不良反应迹象。
罗库溴铵可能是 4 种鸟类的一种良好的扩瞳剂选择，但需要进一步研究以找到降低药物相关副作用的最低有效剂量。
