Third Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan.
Department of Pathology and Oncology, School of Medicine, University of Occupational and Environmental Health, Japan.
Intern Med. 2021 Jul 15;60(14):2235-2240. doi: 10.2169/internalmedicine.6181-20. Epub 2021 Feb 22.
A 75-year-old man visited our hospital for the examination of a tumor in the pancreas. Computed tomography showed an 85×85-mm low-density tumor in the pancreas. The tumor was pathologically diagnosed as poorly differentiated carcinoma by endoscopic ultrasound-guided fine-needle aspiration. Although we started chemotherapy, the patient died 84 days after the diagnosis. An autopsy demonstrated a ruptured anaplastic carcinoma with mucoepidermoid carcinoma of the pancreas. Anaplastic carcinoma with mucoepidermoid carcinoma is a very rare histologic subtype of pancreatic carcinoma, so pathological findings are important for predicting the patient's prognosis. Physicians should be aware of this rare but fatal disease.
一位 75 岁男性因胰腺肿瘤来我院就诊。计算机断层扫描显示胰腺内有一个 85×85mm 的低密度肿瘤。经内镜超声引导下细针抽吸活检，肿瘤病理诊断为低分化癌。尽管我们开始了化疗，但患者在诊断后 84 天死亡。尸检显示胰腺的间变性癌伴黏液表皮样癌破裂。胰腺的间变性癌伴黏液表皮样癌是一种非常罕见的胰腺癌组织学亚型，因此病理发现对于预测患者的预后非常重要。医生应该意识到这种罕见但致命的疾病。
