Kim Yong-Chan, Won Sae-Young, Jeong Byung-Hoon
Korea Zoonosis Research Institute, Jeonbuk National University, 820-120, Hana-ro, Iksan, Jeonbuk 54531 Republic of Korea.
Department of Bioactive Material Sciences, Jeonbuk National University, Jeonju, Jeonbuk 54896 Republic of Korea.
Mol Cell Toxicol. 2021;17(2):179-186. doi: 10.1007/s13273-021-00123-y. Epub 2021 Feb 15.
The interferon-induced transmembrane (IFITM) protein family consists of interferon-stimulated genes (ISGs) that show potent antiviral capacity against a broad range of viruses. Many studies have been performed to investigate an association between polymorphisms and pandemic influenza A 2009 H1N1 virus infection. However, an association study of polymorphisms with susceptibility to this infection has not been reported thus far.
To identify an association between the susceptibility to pandemic influenza A 2009 H1N1 virus infection and polymorphisms, we compared genotype, allele and haplotype frequencies of the gene between healthy controls and pandemic influenza A 2009 H1N1-infected patients. In addition, we investigated linkage disequilibrium (LD) by Haploview 4.2 and the binding ability of transcription factors according to polymorphism alleles by PROMO. Furthermore, we measured the LD value between the gene and the gene.
We found 3 novel single-nucleotide polymorphisms (SNPs) and did not find an association between SNPs and susceptibility to pandemic influenza A 2009 H1N1 virus infection. We found strong LD among SNPs but did not find a difference in the transcription factor-binding ability according to regulatory SNP alleles. In addition, we found strong LD between SNPs and SNPs.
To the best of our knowledge, this report is the first association study of the susceptibility to pandemic influenza A 2009 H1N1 virus infection and polymorphisms.
干扰素诱导跨膜（IFITM）蛋白家族由干扰素刺激基因（ISGs）组成，这些基因对多种病毒具有强大的抗病毒能力。已经进行了许多研究来调查多态性与2009年甲型H1N1大流行性流感病毒感染之间的关联。然而，迄今为止尚未报道多态性与这种感染易感性的关联研究。
为了确定2009年甲型H1N1大流行性流感病毒感染易感性与多态性之间的关联，我们比较了健康对照者和2009年甲型H1N1大流行性流感病毒感染患者之间该基因的基因型、等位基因和单倍型频率。此外，我们通过Haploview 4.2研究连锁不平衡（LD），并通过PROMO根据多态性等位基因研究转录因子的结合能力。此外，我们测量了该基因与该基因之间的LD值。
我们发现了3个新的单核苷酸多态性（SNP），未发现这些SNP与2009年甲型H1N1大流行性流感病毒感染易感性之间存在关联。我们发现这些SNP之间存在强LD，但未发现根据调节性SNP等位基因的转录因子结合能力存在差异。此外，我们发现这些SNP与这些SNP之间存在强LD。
据我们所知，本报告是首次关于2009年甲型H1N1大流行性流感病毒感染易感性与多态性的关联研究。
