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朊蛋白基因（）多态性与2009年大流行性猪流感易感性无关联。

No association of prion protein gene () polymorphisms with susceptibility to the pandemic 2009 swine flu.

作者信息

Kim Yong-Chan, Won Sae-Young, Jeong Byung-Hoon

机构信息

Korea Zoonosis Research Institute, Jeonbuk National University, 820-120, Hana-Ro, Iksan, Jeonbuk 54531 Republic of Korea.

Department of Bioactive Material Sciences and Institute for Molecular Biology and Genetics, Jeonbuk National University, Jeonju, Jeonbuk 54896 Republic of Korea.

出版信息

Mol Cell Toxicol. 2022 Nov 12:1-5. doi: 10.1007/s13273-022-00318-x.

DOI:10.1007/s13273-022-00318-x
PMID:36408482
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9660098/
Abstract

BACKGROUND

The pandemic 2009 swine flu is a highly infectious respiratory disorder caused by H1N1 influenza A viruses. A recent study reported that knockout of the prion protein gene () induced susceptibility and lethality in influenza A virus-infected mice.

OBJECTIVE

Thus, we examined the association between genetic variations of the gene and susceptibility to pandemic 2009 swine flu.

RESULTS

We did not find an association between polymorphisms and susceptibility to pandemic 2009 swine flu.

CONCLUSIONS

To the best of our knowledge, this was the first evaluation of the association between polymorphisms and vulnerability to pandemic 2009 swine flu.

摘要

背景

2009年大流行的猪流感是一种由甲型H1N1流感病毒引起的高传染性呼吸道疾病。最近一项研究报告称，朊病毒蛋白基因（）敲除会导致甲型流感病毒感染小鼠出现易感性和致死性。

目的

因此，我们研究了该基因的遗传变异与2009年大流行猪流感易感性之间的关联。

结果

我们未发现该基因多态性与2009年大流行猪流感易感性之间存在关联。

结论

据我们所知，这是首次评估该基因多态性与2009年大流行猪流感易感性之间的关联。

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Int J Mol Sci. 2021 Feb 25;22(5):2271. doi: 10.3390/ijms22052271.
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