3,4-亚甲基二氧甲基苯丙胺对雄性大鼠海马神经发生的影响。
The Effects of 3,4-methylenedioxymethamphetamine on Neurogenesis in the Hippocampus of Male Rats.
作者信息
Soleimani Asl Sara, Ghasemi Moravej Fahimeh, Kowsari Golshad, Farhadi Mohammad Hassan, Pourhaydar Bagher, Ghasemi Hamidabadi Hatef, Mehdizadeh Mehdi
机构信息
Endometrium and Endometriosis Research Centre, Hamadan University of Medical Sciences, Hamadan, Iran.
School of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.
出版信息
Basic Clin Neurosci. 2020 Jul-Aug;11(4):457-464. doi: 10.32598/bcn.9.10.420. Epub 2020 Jul 1.
INTRODUCTION
The administration of 3,4-methylenedioxymethamphetamine (MDMA) or ecstasy causes memory impairment, whereas neurogenesis improves memory and learning. Hence, this study evaluated the effects of MDMA on neurogenesis in the hippocampus of male rats.
METHODS
Adult male Wistar rats received Intraperitoneal (IP) injections of MDMA (10 mg/ kg). We assessed nestin, sex-determining region Y-box 2 (Sox2), and NeuroD expressions according to the immunohistochemistry analyses.
RESULTS
MDMA reduced the expressions of nestin, Sox2, and NeuroD compared with the control groups. The reduction in NeuroD expression was age-related.
CONCLUSION
MDMA possibly has negative effects on neurogenesis, which specifically results from impaired survival of newborn cells.
引言
服用3,4-亚甲基二氧甲基苯丙胺（MDMA）或摇头丸会导致记忆障碍，而神经发生可改善记忆和学习能力。因此，本研究评估了MDMA对雄性大鼠海马体神经发生的影响。
方法
成年雄性Wistar大鼠腹腔注射MDMA（10毫克/千克）。我们根据免疫组织化学分析评估巢蛋白、性别决定区Y盒2（Sox2）和神经分化因子（NeuroD）的表达。
结果
与对照组相比，MDMA降低了巢蛋白、Sox2和NeuroD的表达。NeuroD表达的降低与年龄有关。
结论
MDMA可能对神经发生有负面影响，这具体是由新生细胞存活受损导致的。
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