Shariati Mohamad Bakhtiar Hesam, Sohrabi Maryam, Shahidi Siamak, Nikkhah Ali, Mirzaei Fatemeh, Medizadeh Mehdi, Asl Sara Soleimani
Research Center for Behavioral Disorders and Substance Abuse, Hamadan University of Medical Sciences, Hamadan, Iran.
Anatomy Department, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Basic Clin Neurosci. 2014 Summer;5(3):225-30.
Exposure to 3, 4- methylenedioxymethamphetamine (MDMA) could lead to serotonergic system toxicity in the brain. This system is responsible for learning and memory functions. Studies show that MDMA causes memory impairment dose-dependently and acutely. The present study was designed to evaluate the chronic and acute effects of MDMD on spatial memory and acquisition of passive avoidance.
Adult male Wistar rats (200-250 g) were given single or multiple injections of MDMA (10 mg/kg, IP). Using passive avoidance and Morris Water Maze (MWM) tasks, learning and spatial memory functions were assessed. The data were analyzed by SPSS 16 software and one- way analysis of variance (ANOVA) test.
Our results showed that there were significant differences in latency to enter the dark compartment (STL) between sham and MDMA- treated groups. Acute group significantly showed more STL in comparison with chronic group. Furthermore, MDMA groups spent more time in dark compartment (TDS) than the sham group. Administration of single dose of MDMA significantly caused an increase in TDS compared with the chronic group. In the MWM, MDMA treatment significantly increased the traveled distance and escaped latency compared to the sham group. Like to passive avoidance task, percentage of time spent in the target quadrant in MDMA- treated animals impaired in MWM compared with sham group.
These data suggest that MDMA treatment impairs learning and memory functions that are more extensive in acute- treated rats.
接触3,4-亚甲基二氧甲基苯丙胺（摇头丸）可导致大脑中5-羟色胺能系统中毒。该系统负责学习和记忆功能。研究表明，摇头丸会剂量依赖性地急性导致记忆障碍。本研究旨在评估摇头丸对空间记忆和被动回避习得的慢性和急性影响。
成年雄性Wistar大鼠（200-250克）接受单次或多次注射摇头丸（10毫克/千克，腹腔注射）。使用被动回避和莫里斯水迷宫（MWM）任务评估学习和空间记忆功能。数据通过SPSS 16软件和单因素方差分析（ANOVA）进行分析。
我们的结果表明，假手术组和摇头丸处理组之间进入暗室的潜伏期（STL）存在显著差异。急性组与慢性组相比，STL明显更长。此外，摇头丸组在暗室中花费的时间（TDS）比假手术组更多。与慢性组相比，单次注射摇头丸显著导致TDS增加。在MWM中，与假手术组相比，摇头丸处理显著增加了游动距离和逃避潜伏期。与被动回避任务一样，与假手术组相比，摇头丸处理动物在MWM中在目标象限花费的时间百分比受损。
这些数据表明，摇头丸处理会损害学习和记忆功能，在急性处理的大鼠中这种损害更广泛。
