Tang Ying, Jiang Mei, Jiang Hai-Mei, Ye Zeng Jie, Huang Yu-Sheng, Li Xiu-Shen, Qin Bin-Yu, Zhou Rui-Sheng, Pan Hua-Feng, Zheng Da-Yong
Department of Oncology, Institute of Tumor, Guangzhou University of Chinese Medicine, Guangzhou, China.
Department of Oncology, Lingnan Medical Research Center of Guangzhou University of Chinese Medicine, Guangzhou, China.
Front Oncol. 2021 Feb 4;10:598464. doi: 10.3389/fonc.2020.598464. eCollection 2020.
Circular RNAs (circRNAs) are stable covalently closed non-coding RNAs (ncRNAs). Many studies indicate that circRNAs are involved in the pathological and physiological processes of liver cancer. However, the functions of circRNAs in liver cancer immunity are less known. In this review, we summarized the functions of circRNAs in liver cancer, including proliferative, metastasis and apoptosis, liver cancer stemness, cell cycle, immune evasion, glycolysis, angiogenesis, drug resistance/sensitizer, and senescence. Immune escape is considered to be one of the hallmarks of cancer development, and circRNA participates in the immune escape of liver cancer cells by regulating natural killer (NK) cell function. CircRNAs may provide new ideas for immunotherapy in liver cancer.
环状RNA（circRNAs）是稳定的共价闭合非编码RNA（ncRNAs）。许多研究表明，circRNAs参与了肝癌的病理和生理过程。然而，circRNAs在肝癌免疫中的功能尚鲜为人知。在本综述中，我们总结了circRNAs在肝癌中的功能，包括增殖、转移和凋亡、肝癌干性、细胞周期、免疫逃逸、糖酵解、血管生成、耐药性/敏感性以及衰老。免疫逃逸被认为是癌症发展的标志之一，circRNA通过调节自然杀伤（NK）细胞功能参与肝癌细胞的免疫逃逸。CircRNAs可能为肝癌免疫治疗提供新思路。
