从头设计选择性四链体-双链连接配体及其结合模式的结构特征：针对 G4 热点。
De Novo Design of Selective Quadruplex-Duplex Junction Ligands and Structural Characterisation of Their Binding Mode: Targeting the G4 Hot-Spot.
机构信息
Glycochemistry and Molecular Recognition group-Dpt. Bio-Organic Chemistry, Instituto de Química Orgánica General (IQOG-CSIC), Juan de la Cierva 3., 28006, Madrid, Spain.
Instituto de Química-Física Rocasolano (IQFR-CSIC), Serrano 119., 28006, Madrid, Spain.
出版信息
Chemistry. 2021 Apr 7;27(20):6106. doi: 10.1002/chem.202100456. Epub 2021 Feb 22.
Invited for the cover of this issue are Andrés G. Santana, Carlos González, Juan Luis Asensio and co-workers at Instituto de Química Orgánica General, Instituto de Química-Física Rocasolano and Universidad de La Rioja. The image depicts drug selectivity using a metaphor of an arrow hitting a target. Read the full text of the article at 10.1002/chem.202005026.
本期特邀封面人物为安德烈斯·G·桑塔纳（Andrés G. Santana）、卡洛斯·冈萨雷斯（Carlos González）、胡安·路易斯·阿森西奥（Juan Luis Asensio）以及里奥哈大学、西班牙综合有机化学研究所和罗卡索拉诺物理化学研究所的同事们。该图片通过箭靶的隐喻来描绘药物的选择性。文章全文可在 10.1002/chem.202005026 查看。
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