Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Obes Rev. 2021 May;22(5):e13166. doi: 10.1111/obr.13166. Epub 2020 Dec 4.
Transcription factor 7-like 2 (TCF7L2), a member of the T cell factor/lymphoid enhancer factor family, generally forms a complex with β-catenin to regulate the downstream target genes as an effector of the canonical Wnt signalling pathway. TCF7L2 plays a vital role in various biological processes and functions in many organs and tissues, including the liver, islet and adipose tissues. Further, TCF7L2 down-regulates hepatic gluconeogenesis and promotes lipid accumulation. In islets, TCF7L2 not only affects the insulin secretion of the β-cells but also has an impact on other cells. In addition, TCF7L2 influences adipogenesis in adipose tissues. Thus, an out-of-control TCF7L2 expression can result in metabolic disorders. The TCF7L2 gene is composed of 17 exons, generating 13 different transcripts, and has many single-nucleotide polymorphisms (SNPs). The discovery that these SNPs have an impact on the risk of type 2 diabetes (T2D) has attracted thorough investigations in the study of TCF7L2. Apart from T2D, TCF7L2 SNPs are also associated with type 1, posttransplant and other types of diabetes. Furthermore, TCF7L2 variants affect the progression of other disorders, such as obesity, cancers, metabolic syndrome and heart diseases. Finally, the interaction between TCF7L2 variants and diet also needs to be investigated.
转录因子 7 样 2（TCF7L2）是 T 细胞因子/淋巴增强因子家族的成员，通常与β-连环蛋白形成复合物，作为经典 Wnt 信号通路的效应物调节下游靶基因。TCF7L2 在各种生物过程中发挥着重要作用，在许多器官和组织中发挥功能，包括肝脏、胰岛和脂肪组织。此外，TCF7L2 下调肝糖异生并促进脂质积累。在胰岛中，TCF7L2 不仅影响β细胞的胰岛素分泌，而且对其他细胞也有影响。此外，TCF7L2 影响脂肪组织中的脂肪生成。因此，TCF7L2 表达失控可导致代谢紊乱。TCF7L2 基因由 17 个外显子组成，产生 13 种不同的转录本，并且具有许多单核苷酸多态性（SNP）。这些 SNP 影响 2 型糖尿病（T2D）风险的发现引起了 TCF7L2 研究的深入调查。除了 T2D，TCF7L2 SNP 还与 1 型、移植后和其他类型的糖尿病有关。此外，TCF7L2 变体影响其他疾病的进展，如肥胖、癌症、代谢综合征和心脏病。最后，还需要研究 TCF7L2 变体与饮食之间的相互作用。
