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胎儿头位异常与分娩时硬膜外镇痛:病例对照研究。

Fetal head malposition and epidural analgesia in labor: a case-control study.

机构信息

International Doctorate School in Clinical and Experimental Medicine, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.

Obstetrics and Gynecology Unit, Mother-Infant Department, Policlinic Hospital, University of Modena and Reggio-Emilia, Modena, Italy.

出版信息

J Matern Fetal Neonatal Med. 2022 Dec;35(25):5691-5696. doi: 10.1080/14767058.2021.1890018. Epub 2021 Feb 21.

Abstract

BACKGROUND

The fetal head malposition in labor leads to prolonged labor, cesarean delivery and increased perinatal morbidity. Epidural analgesia has been associated with fetal head malposition, but it remains unknown if this relation is causal.

OBJECTIVE

To compare the incidence of fetal malposition during labor and maternal/fetal outcomes, between women who received epidural analgesia with those who did not use the analgesic method.

STUDY DESIGN

Case control study including 500 women with a single fetus in vertex position who gave birth at term at the Policlinic Hospital of Modena between May 2019 and July 2019. Two-hundred and fifty women belonged to the (EA) group and 250 to the group.

RESULTS

The rate of posterior occiput positions occurred 4 times more frequently in the EA group than in the control group (8.8% vs 2.2%,  = .004). Cesarean sections were significantly higher in the EA group (11.6% vs 1.6%,  < .0000) as well as the need for augmentation with oxytocin (20% vs 8%,  = .0001) compared to the control group, in which spontaneous delivery prevailed instead. Women with epidural had labors that lasted on average 7.0 h against the 3.30 h of controls ( < .0000). The length of 2nd stage of labor was 55 vs 30 min ( = .009), respectively. No differences in blood loss and Apgar score between groups. Early breastfeeding was significantly higher among controls (82% vs 92.8%,  = .0004).

CONCLUSIONS

Women receiving epidural analgesia in labor have higher rate of fetal malposition, prolonged labors, and more cesarean sections than controls. However, further studies are required to confirm a causal association between EA and fetal head malposition.

摘要

背景

分娩时胎儿头部位置异常会导致产程延长、剖宫产和围产儿发病率增加。硬膜外镇痛与胎儿头部位置异常有关,但尚不清楚这种关系是否具有因果关系。

目的

比较接受硬膜外镇痛的产妇与未使用镇痛方法的产妇在分娩时胎儿位置异常以及母婴/胎儿结局的发生率。

研究设计

这是一项包括 500 名单胎头位足月产妇的病例对照研究,她们于 2019 年 5 月至 7 月在摩德纳综合医院分娩。250 名产妇属于硬膜外镇痛组(EA 组),250 名产妇属于对照组。

结果

EA 组的后枕骨位发生率是对照组的 4 倍(8.8% vs. 2.2%,= 0.004)。EA 组剖宫产率明显高于对照组(11.6% vs. 1.6%,< 0.0000),催产素引产的需求也明显高于对照组(20% vs. 8%,= 0.0001),对照组以自然分娩为主。接受硬膜外镇痛的产妇产程平均持续 7.0 小时,而对照组为 3.30 小时(< 0.0000)。第二产程时长分别为 55 分钟和 30 分钟(= 0.009)。两组产妇的出血量和阿普加评分无差异。对照组的早期母乳喂养率明显更高(82% vs. 92.8%,= 0.0004)。

结论

分娩时接受硬膜外镇痛的产妇胎儿位置异常发生率较高,产程延长,剖宫产率较高。然而,需要进一步的研究来证实 EA 和胎儿头部位置异常之间的因果关系。

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