Centre for Human Psychopharmacology, Swinburne University of Technology, Advanced Technologies Centre, Hawthorn, Australia.
Professorial Unit, the Melbourne Clinic, Department of Psychiatry, Melbourne University, Richmond, Australia.
Exp Aging Res. 2021 Jul-Sep;47(4):322-346. doi: 10.1080/0361073X.2021.1883966. Epub 2021 Feb 20.
F-Isoprostanes are putative markers of oxidative stress, one of the processes associated with biological senescence. Evidence exists for elevated F-Isoprostanes in chronic conditions including psychiatric disorders. Few studies have examined the relationship between oxidative stress and mood in older healthy samples, to establish the influence on mental health. Given current aging demographics in many nations, management of brain and mental health is crucial for longevity, chronic disease management, and quality of life. We investigated the relationship between F-Isoprostanes, a marker for oxidative stress, and anxiety and mood in 262 healthy adults aged 60-75 years, using baseline data from the Australian Research Council Longevity Intervention (ARCLI; ANZCTR12611000487910), a 12-month nutraceutical intervention study. Higher F2 levels significantly predicted increased Depression-dejection and Anger-hostility subscale scores from the Profile of Mood States (POMS). Fatigue-inertia subscale was predicted by increased Body Mass Index. Spielberger State-Trait Inventory (STAI) scores were significantly higher in females. While the primary outcome data did not find a definitive relationship between F2 and total mood or general anxiety levels, the sub-scale data adds weight toward growing literature that biological processes such as oxidative stress are in part related to mood. This is a modifiable risk factor contributing to physical and mental wellbeing that are crucial to healthy aging.
F-型前列腺素是氧化应激的假定标志物，氧化应激是与生物衰老相关的过程之一。有证据表明，在包括精神障碍在内的慢性疾病中，F-型前列腺素水平升高。少数研究调查了氧化应激与老年健康人群情绪之间的关系，以确定其对心理健康的影响。鉴于许多国家目前的人口老龄化趋势，大脑和心理健康的管理对于长寿、慢性病管理和生活质量至关重要。我们使用澳大利亚研究委员会长寿干预研究（ARCLI；ANZCTR12611000487910）的基线数据，该研究是一项为期 12 个月的营养干预研究，调查了 262 名 60-75 岁健康成年人的 F-型前列腺素（氧化应激标志物）与焦虑和情绪之间的关系。更高的 F2 水平显著预测了心境状态问卷（POMS）中抑郁沮丧和愤怒敌意子量表评分的增加。疲劳-惰性子量表由体重指数增加预测。女性的斯皮尔伯格状态-特质焦虑量表（STAI）评分显著较高。虽然主要结果数据没有发现 F2 与总体情绪或一般焦虑水平之间存在明确的关系，但子量表数据增加了越来越多的文献的权重，即生物过程如氧化应激在一定程度上与情绪有关。这是一个可改变的风险因素，对身心健康至关重要，是健康老龄化的关键。
