Julius U, Leonhardt W
Clinic of Internal Medicine, Medical Academy Carl Gustav Carus, Dresden, GDR.
JPEN J Parenter Enteral Nutr. 1988 Mar-Apr;12(2):116-20. doi: 10.1177/0148607188012002116.
Medium chain triglycerides (MCT) are supposed to be advantageous on account of rapid energy supply in parental nutrition. However, data on the elimination rate of MCT-containing emulsions during an intravenous fat-tolerance test (IVFTT) are scarce. We performed this test (0.1 g lipid/kg body weight) in 18 young healthy volunteers (nine females and nine males) using Lipofundin MCT 10% (50% MCT; egg phospholipids as emulsifier). Our results indicate that both elimination and metabolization of the emulsion are fast: a prompt decrease of light-scattering index and of triglyceride concentrations in serum, an immediate appearance of post-load fatty acids and of beta-hydroxybutyrate were observed. This was in good agreement with the findings obtained during 6-hr infusions in the same probands. Fractional elimination rates k2 obtained from light-scattering indices are 7.29 +/- 2.73%/min in males and 11.59 +/- 3.38%/min in females, indicating a higher removal capacity in women. In the same subjects, the corresponding k2 values for Lipofundin S 10% (containing only long chain triglycerides) were higher, reflecting an elimination rate that is faster due to the use of soya bean phospholipids as emulsifier. In comparison, k2 values based on the course of the triglyceride concentrations are generally lower.
中链甘油三酯（MCT）因在肠外营养中能快速提供能量而被认为具有优势。然而，关于含MCT乳剂在静脉脂肪耐量试验（IVFTT）期间的清除率的数据却很少。我们使用10% Lipofundin MCT（50% MCT；以蛋黄磷脂为乳化剂）对18名年轻健康志愿者（9名女性和9名男性）进行了该试验（0.1 g脂质/千克体重）。我们的结果表明，该乳剂的清除和代谢都很快：观察到散射指数和血清中甘油三酯浓度迅速下降，负荷后脂肪酸和β-羟基丁酸立即出现。这与在同一受试者6小时输注期间获得的结果非常一致。从散射指数得出的男性的分数清除率k2为7.29±2.73%/分钟，女性为11.59±3.38%/分钟，表明女性的清除能力更高。在同一受试者中，10% Lipofundin S（仅含长链甘油三酯）的相应k2值更高，这反映出由于使用大豆磷脂作为乳化剂，清除率更快。相比之下，基于甘油三酯浓度变化过程的k2值通常较低。
