Leonhardt W, Julius U, Schulze J, Hanefeld M, Haller H
JPEN J Parenter Enteral Nutr. 1985 Jul-Aug;9(4):461-3. doi: 10.1177/0148607185009004461.
The intravenous fat tolerance test with Lipofundin S (0.5 ml of 20% emulsion/kg body weight) was performed in 22 male nondiabetic patients. According to their fasting triglycerides (TG), the patients were arranged into three groups: low (less than 2.8 mmol/liter), medium (2.8-5.7 mmol/liter), and high (greater than 5.7 mmol/liter) concentrations. Fractional elimination rates of injected Lipofundin S decreased from 11.08 in low TG to 4.57%/min in high TG; they were positively correlated with fasting levels of high-density lipoprotein cholesterol but negatively with those of TG. The same pattern of correlations was observed with fractional catabolic rates of endogenous TG as measured after injection of tritium-labeled glycerol. The intravenous Lipofundin S load effected transient TG and free fatty acid elevations which were delayed in high TG. The elimination mechanisms of injected Lipofundin S and of endogenous TG are compared.
对22名男性非糖尿病患者进行了用Lipofundin S（0.5毫升20%乳剂/千克体重）的静脉脂肪耐量试验。根据他们的空腹甘油三酯（TG）水平，将患者分为三组：低浓度组（低于2.8毫摩尔/升）、中浓度组（2.8 - 5.7毫摩尔/升）和高浓度组（高于5.7毫摩尔/升）。注射的Lipofundin S的分数消除率从低TG组的11.08降至高TG组的4.57%/分钟；它们与高密度脂蛋白胆固醇的空腹水平呈正相关，但与TG的空腹水平呈负相关。注射氚标记甘油后，内源性TG的分解代谢率也观察到了相同的相关模式。静脉注射Lipofundin S负荷导致TG和游离脂肪酸短暂升高，在高TG组中这种升高出现延迟。比较了注射的Lipofundin S和内源性TG的消除机制。
