Neuroscience Institute, Georgia State University, Atlanta, GA, USA.
Department of Biology, Georgia State University, Atlanta, GA, USA.
J Neuroendocrinol. 2021 Jan;33(1):e12915. doi: 10.1111/jne.12915. Epub 2020 Dec 7.
Vasopressin (AVP) cells in the paraventricular nucleus of the hypothalamus (PVN) are activated during sickness and project to multiple nuclei responsible for the anxiety, social and motivated behaviours affected during sickness, suggesting that these cells may play a role in sickness behaviours, typically expressed as reduced mobility, increased anxiety, anhedonia and social withdrawal. In the present study, we selectively ablated AVP neurones in the PVN of male and female mice (Mus musculus) and induced sickness behaviour via injection of bacterial lipopolysaccharide (LPS). We found that PVN AVP ablation increased the effects of LPS, specifically by further decreasing sucrose preference in males and females and decreasing the social preference of males, monitored within 24 hours of LPS injection. These results suggest that PVN AVP contributes to the change in motivated behaviours during sickness and may help promote recovery from infection..
下丘脑室旁核中的加压素 (AVP) 细胞在患病时被激活，并投射到多个核，这些核负责患病时出现的焦虑、社交和动机行为，这表明这些细胞可能在患病行为中发挥作用，通常表现为活动减少、焦虑增加、快感缺失和社交退缩。在本研究中，我们选择性地破坏了雄性和雌性小鼠（Mus musculus）室旁核中的 AVP 神经元，并通过注射细菌脂多糖（LPS）诱导患病行为。我们发现，PVN AVP 消融增加了 LPS 的作用，具体表现为雄性和雌性动物的蔗糖偏好进一步降低，以及雄性动物的社交偏好降低，这是在 LPS 注射后 24 小时内监测到的。这些结果表明，PVN AVP 有助于患病期间动机行为的变化，并可能有助于从感染中恢复。
