Provincial Agency for Health of the Autonomous Province of Trento, Trento, Italy.
Department of Health Science, Faculty of Science, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, The Netherlands.
Brain Inj. 2021 Mar 21;35(4):385-394. doi: 10.1080/02699052.2021.1887522. Epub 2021 Feb 22.
To examine the effectiveness of median nerve electrical stimulation on consciousness level in subjects with disorders of consciousness.
Electronic databases PubMed, EMBASE, CENTRAL, and PEDro, as well as manual search and gray literature were searched from inception until May 2019. We included only randomized controlled trials. Two reviewers independently conducted the search strategy, study selection, data extraction, risk of bias assessment, and evidence judgment quality.
Five studies met the inclusion criteria. Overall, no clear conclusion can be drawn about the intervention's effectiveness on the level of consciousness. One study reported a benefit of the intervention on the number of hospitalization days in the intensive care unit. Furthermore, another study reported a higher percentage of patients who regained consciousness six months from the event in the experimental group.
Due to the limited number of studies that met the inclusion criteria and overall high risk of bias, it is impossible to draw a definitive conclusion. The results of this systematic review should be used to improve future research in this field.
研究正中神经电刺激对意识障碍患者意识水平的影响。
计算机检索 PubMed、EMBASE、CENTRAL、PEDro 数据库及手工检索和灰色文献，检索时限均从建库至 2019 年 5 月，纳入正中神经电刺激治疗意识障碍的随机对照试验。由 2 位评价员独立进行检索策略制定、文献筛选、资料提取、偏倚风险评估及证据质量评价。
最终纳入 5 项研究。总体而言，尚不能明确该干预措施对意识水平的影响。有 1 项研究报道干预组患者在重症监护病房的住院天数有获益。此外，另一项研究报道试验组患者在事件发生后 6 个月恢复意识的比例更高。
由于纳入研究数量较少，且总体偏倚风险较高，无法得出明确结论。本系统评价的结果应有助于改进该领域的未来研究。
