Division of Nephrology, Federal University of São Paulo, Brazil; Department of Physiological Sciences, Federal University of Maranhão, Brazil.
Division of Nephrology, Federal University of São Paulo, Brazil.
Metabolism. 2021 May;118:154738. doi: 10.1016/j.metabol.2021.154738. Epub 2021 Feb 19.
The global nephrology community recognizes the increasing burden of kidney disease and its poor health outcomes in the general population. Given this, strategies to establish early diagnosis, improve understanding of the natural course and develop novel therapeutic interventions to slow progression and reduce complications are encouraged. Fibroblast growth factor 21 (FGF21), a member of the endocrine FGF subfamily, has emerged as a master homeostasis regulator of local and systemic lipid, glucose and energy metabolism. In addition, FGF21 should be considered an autonomic and endocrine regulator of stress responses in general. Promising results has been shown in both dysmetabolic animal models and metabolic disease patients after pharmacological administration of FGF21 analogs. The association of FGF21 with renal function has been studied for more than ten years. However, the functional role of FGF21 in the kidney is still poorly understood. This review summarizes the biological effects of FGF21 and discusses what is currently known about this hormone and chronic kidney disease, highlighting important gaps that warrant further research.
全球肾脏病学界认识到肾脏疾病负担日益加重，以及其在普通人群中的不良健康结局。有鉴于此，鼓励采取各种策略，以便早期诊断，加深对自然病程的理解，并研发新的治疗干预措施，以减缓疾病进展，减少并发症。成纤维细胞生长因子 21（FGF21）是内分泌 FGF 亚家族的成员，已成为局部和全身脂质、葡萄糖和能量代谢的主要内稳态调节剂。此外，FGF21 通常还被视为自主和内分泌应激反应的调节剂。在代谢紊乱的动物模型和接受 FGF21 类似物药物治疗的代谢疾病患者中，均观察到了有前景的结果。FGF21 与肾功能的相关性已研究了十多年，但 FGF21 在肾脏中的功能作用仍知之甚少。本综述总结了 FGF21 的生物学作用，并讨论了目前已知的关于该激素与慢性肾脏病的知识，强调了需要进一步研究的重要空白。
