Royal National ENT Hospital, London, UK.
Royal Brompton Hospital, London, UK.
J Allergy Clin Immunol Pract. 2021 May;9(5):1851-1857. doi: 10.1016/j.jaip.2021.02.013. Epub 2021 Feb 20.
Advances in our understanding of the immune system, with the recent discovery of a parallel set of innate T lymphocytes, the innate lymphocytes (ILCs), have led to a reassessment of the pathogenesis of allergic and eosinophilic airway disorders, including allergic rhinitis (AR), asthma, and chronic rhinosinusitis with nasal polyps. We review current understanding of both elements of type-2 inflammatory responses and their relative influence in these common conditions and consider possible impacts of this on treatment selection.
随着最近对先天 T 淋巴细胞（即先天淋巴细胞）这一平行免疫细胞群的发现，我们对过敏性和嗜酸性气道疾病（包括过敏性鼻炎[AR]、哮喘和伴有鼻息肉的慢性鼻-鼻窦炎）的发病机制有了更深入的了解。我们回顾了 2 型炎症反应的这两个要素的现有认识及其在这些常见疾病中的相对影响，并考虑了这对治疗选择的可能影响。
