Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Department of Biology, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Int J Food Sci Nutr. 2021 Nov;72(7):923-934. doi: 10.1080/09637486.2021.1886255. Epub 2021 Feb 22.
Obesity is a global health concern associated with the dysbiosis of intestinal microbial composition. In this study, we investigated the potentials of urolithin A (Uro-A) and urolithin B (Uro-B), two gut microbiota-derived metabolites of ellagitannins, in reducing body weight gain through the modulation of the gut microbiota. We established a high-fat diet (HFD)-induced obesity model in rats that were later administered with either 2.5 mg/kg of Uro-A or Uro-B. Serum biochemical parameters were quantified, and changes in the composition of the gut microbial community were analysed using 16S rDNA gene sequencing. Our results showed that the urolithins significantly decreased the body weight in HFD-fed rats and restored serum lipid profile. The taxonomic analysis showed that both Uro-A and Uro-modulated gut microbes related to body weight, dysfunctional lipid metabolism and inflammation. Overall, our results suggest that Uro-A and Uro-B possess anti-obesity properties, which may be related to the modulation of the gut microbial composition.
肥胖是一个全球性的健康问题，与肠道微生物组成的失调有关。在这项研究中，我们研究了尿石素 A（Uro-A）和尿石素 B（Uro-B）的潜力，它们是鞣花单宁的两种肠道微生物衍生代谢物，通过调节肠道微生物群来减少体重增加。我们建立了高脂肪饮食（HFD）诱导的肥胖大鼠模型，然后用 2.5mg/kg 的 Uro-A 或 Uro-B 进行治疗。定量了血清生化参数，并通过 16S rDNA 基因测序分析了肠道微生物群落组成的变化。我们的结果表明，尿石素显著降低了 HFD 喂养大鼠的体重，并恢复了血清脂质谱。分类分析表明，Uro-A 和 Uro-B 都调节了与体重、脂代谢功能障碍和炎症相关的肠道微生物。总的来说，我们的结果表明 Uro-A 和 Uro-B 具有抗肥胖特性，这可能与调节肠道微生物组成有关。
