Pontifícia Universidade Católica do Paraná, Curitiba, Paraná, Brazil.
Business School, Pontifícia Universidade Católica do Paraná, Curitiba, PR, Brazil.
Infect Control Hosp Epidemiol. 2021 Dec;42(12):1445-1450. doi: 10.1017/ice.2021.22. Epub 2021 Feb 23.
To evaluate the impact of outpatient parenteral antimicrobial therapy (OPAT) on a public hospital in a middle-income country.
A retrospective, observational study analyzing the economic data retrieved on the dehospitalization of patients on antibiotic therapy.
Public university trauma hospital.
Data were collected from June 2017 to May 2020. Antibiotic cost, hospital length of stay, and risk of multidrug-resistant (MDR) infection or colonization were reviewed, along with the break-even point at which a balance occurs between OPAT antimicrobial costs and all in-hospital costs. A cumulative risk curve was constructed showing the incidence of MDR during the review period.
In total, 225 patients were studied. The implementation of OPAT resulted in a reduction of $156,681 (49.6%), which is equivalent to an average of $696 per patient, as well as a shortened length of stay, from 33.5 to 15.7 days. OPAT reduces the risk of acquiring infection by MDR bacteria by having the final treatments administered outside of the hospital environment. The breakeven curves, comparing the duration of the OPAT to daily medication costs, allowed for the prediction of the time and dollar costs of antibiotic therapy.
OPAT presented a significant cost savings, shortened length of stay, and reduced risk of contamination of patients by MDR.
评估在中等收入国家的一家公立医院开展门诊静脉注射抗菌治疗（OPAT）的影响。
一项回顾性观察性研究，分析了对接受抗生素治疗的出院患者的经济数据。
公立大学创伤医院。
数据收集自 2017 年 6 月至 2020 年 5 月。评估了抗生素费用、住院时间以及多重耐药（MDR）感染或定植的风险，同时还评估了 OPAT 抗菌药物成本与所有住院费用平衡的平衡点。构建了一条累积风险曲线，显示了在审查期间 MDR 的发生率。
共研究了 225 名患者。实施 OPAT 可减少 156681 美元（49.6%），相当于每位患者平均减少 696 美元，同时住院时间也从 33.5 天缩短至 15.7 天。OPAT 通过在医院环境之外进行最终治疗，降低了获得 MDR 细菌感染的风险。比较 OPAT 持续时间与每日药物费用的平衡曲线，可以预测抗生素治疗的时间和费用。
OPAT 可显著节省成本、缩短住院时间，并降低 MDR 污染患者的风险。
