Pathology and Cell Biology, USF Health Morsani College of Medicine, Tampa, Florida, USA.
Pathology and Cell Biology, and Ophthalmology, Morsani College of Medicine, Tampa, Florida, USA
J Clin Pathol. 2022 May;75(5):354-358. doi: 10.1136/jclinpath-2020-207302. Epub 2021 Feb 22.
Conjunctival squamous intraepithelial neoplasia (CSIN) represents the in situ precursor of squamous cell carcinoma. The graded severity of intraepithelial dysplasia is considered a measure of risk for progression to invasive carcinoma. The range of cytoarchitectural changes in CSIN overlaps those of reactive atypia, squamous epithelial papilloma and in situ sebaceous carcinoma. Pseudoepitheliomatous hyperplasia and benign hereditary dyskeratosis of the conjunctiva are conditions without risk of neoplastic transform that are potentially mistaken for CSIN.
结膜鳞状上皮内瘤变（CSIN）是鳞状细胞癌的原位前体。上皮内异型增生的严重程度分级被认为是向浸润性癌进展的风险指标。CSIN 的细胞结构改变范围与反应性异型、鳞状上皮乳头状瘤和原位皮脂腺癌重叠。假性上皮瘤样增生和结膜良性遗传性角化不良是无肿瘤转化风险的疾病，可能被误诊为 CSIN。
