Dasmahapatra H K, Coles J G, Wilson G J, Sherret H, Adler S, Williams W G, Trusler G A
Division of Cardiovascular Surgery, Hospital for Sick Children, Toronto, Ontario, Canada.
J Thorac Cardiovasc Surg. 1988 May;95(5):920-3.
This study was designed to assess the effects of hemodynamic changes and cerebrospinal fluid dynamics on spinal cord function during experimental thoracic aortic occlusion. We investigated the effects of dopamine, sodium nitroprusside, and sodium thiopental in this model. Proximal and distal aortic pressures and cerebrospinal fluid pressure were measured during occlusion in 12 adult mongrel dogs under control conditions and during drug interventions. Spinal cord function was assessed by spinal somatosensory evoked potentials recorded during 3-minute intervals of reversible spinal cord ischemia. By multiple regression analysis, the degree of spinal cord ischemia was positively related to the cerebrospinal fluid pressure (p = 0.0092) and negatively related to the percent change in cerebrospinal fluid pressure (p = 0.028); there were no significant drug effects on cerebrospinal fluid pressure or on the degree of spinal cord ischemia. This study indicates that cerebrospinal fluid pressure is an important factor in determining the degree of spinal cord ischemia during aortic occlusion and suggests that measures to reduce cerebrospinal fluid pressure will mitigate the degree of spinal cord ischemia.
本研究旨在评估实验性胸主动脉阻断期间血流动力学变化和脑脊液动力学对脊髓功能的影响。我们在该模型中研究了多巴胺、硝普钠和硫喷妥钠的作用。在12只成年杂种犬的对照条件下和药物干预期间，阻断主动脉时测量近端和远端主动脉压力以及脑脊液压力。通过在可逆性脊髓缺血的3分钟间隔期间记录的脊髓体感诱发电位来评估脊髓功能。通过多元回归分析，脊髓缺血程度与脑脊液压力呈正相关（p = 0.0092），与脑脊液压力变化百分比呈负相关（p = 0.028）；药物对脑脊液压力或脊髓缺血程度无显著影响。本研究表明，脑脊液压力是决定主动脉阻断期间脊髓缺血程度的重要因素，并提示降低脑脊液压力的措施将减轻脊髓缺血程度。
