Stenbäck F, Weisburger J H, Williams G M
American Health Foundation, Valhalla, NY 10595.
Mech Ageing Dev. 1988 Feb;42(2):129-38. doi: 10.1016/0047-6374(88)90068-1.
The effects of lifetime treatment with dimethylaminoethanol on longevity and cryptogenic neoplasm formation were studied in females of two mouse sub-lines, the C3H/HeN which carries a germinal mammary tumor provirus and the C3H/HeJ(+) which also carries the exogenous mammary tumor virus. Administration in the drinking water of 10 mM dimethylaminoethanol to the C3H/HeN mice or 15 mM to the C3H/HeJ(+) mice did not result in significant differences between treated and untreated groups in average survival. No changes in age-related organ structure or morphology were observed with dimethylaminoethanol treatment, except for an apparent decrease in the amount of lipofuscin in the liver judged in histological sections. Among untreated C3H/HeJ(+) females, 89% developed neoplasms of the mammary gland, ovary, liver, lung and reticuloendothelial system, while the incidence was 88% in the treated mice. In C3H/HeN females, neoplasms of the mammary gland, ovary, liver, lung and lymphatic system occurred in 57% and in 60% of treated mice. Also, there was no statistically significant difference between control and treated animals in the age of onset or the type of specific neoplasms. Dimethylaminoethanol did not induce any neoplasms.
在两个小鼠亚系的雌性小鼠中研究了用二甲基乙醇进行终身治疗对寿命和隐源性肿瘤形成的影响，这两个亚系分别是携带致瘤性乳腺肿瘤前病毒的C3H/HeN和也携带外源性乳腺肿瘤病毒的C3H/HeJ(+)。给C3H/HeN小鼠饮用含10 mM二甲基乙醇的水，给C3H/HeJ(+)小鼠饮用含15 mM二甲基乙醇的水，处理组和未处理组在平均存活时间上没有显著差异。用二甲基乙醇处理未观察到与年龄相关的器官结构或形态变化，只是在组织学切片中判断肝脏中的脂褐素量明显减少。在未处理的C3H/HeJ(+)雌性小鼠中，89%发生了乳腺、卵巢、肝脏、肺和网状内皮系统的肿瘤，而处理组小鼠的发生率为88%。在C3H/HeN雌性小鼠中，乳腺、卵巢、肝脏、肺和淋巴系统的肿瘤在未处理小鼠中的发生率为57%，在处理小鼠中的发生率为60%。此外，在发病年龄或特定肿瘤类型方面，对照组和处理组动物之间没有统计学上的显著差异。二甲基乙醇未诱发任何肿瘤。
