Hildesheimer M, Muchnik H, Rubinstein M
School for Communication Disorders, Speech and Hearing, Haim Sheba Medical Center, Tel Hashomer, Israel.
Laryngoscope. 1988 May;98(5):557-60. doi: 10.1288/00005537-198805000-00016.
A relatively restricted area, including the ear, was perfused in guinea pigs with hypoxic blood having a pO2 of 10, 20, and 30 mm Hg, respectively. The changes induced to the cochlear action potentials were analyzed and the results compared with those obtained in a previous study in which the guinea pigs were rendered hypoxemic by ventilating them with air entrapped in a closed circuit from which the CO2 was continuously absorbed. The changes induced to the cochlear action potentials by both methods were very similar. However, while using the territorial model for inducing hypoxia, 75% of the animals showed a threshold shift at a blood pO2 of 20 mm Hg and with the general model all the animals showed a threshold shift at 25 mm Hg blood pO2. In other words, if the hypoxic condition affected the whole body, other factors such as a slight, but continuous tendency to acidosis with significant increase in blood lactic acid concentration could join the oxygen deficit in affecting cochlear function.
在豚鼠中，分别用氧分压为10、20和30毫米汞柱的缺氧血液灌注包括耳朵在内的相对受限区域。分析了对耳蜗动作电位诱导的变化，并将结果与先前一项研究的结果进行比较，在先前的研究中，通过用封闭回路中截留的空气对豚鼠进行通气，不断吸收其中的二氧化碳，从而使豚鼠处于低氧血症状态。两种方法对耳蜗动作电位诱导的变化非常相似。然而，在用区域模型诱导缺氧时，75%的动物在血液氧分压为20毫米汞柱时出现阈值偏移，而在用整体模型时，所有动物在血液氧分压为25毫米汞柱时出现阈值偏移。换句话说，如果缺氧状况影响全身，其他因素，如轻微但持续的酸中毒倾向以及血液乳酸浓度显著升高，可能会与缺氧共同影响耳蜗功能。
