Haupt H, Scheibe F, Ludwig C
HNO-Klinik des Universitätsklinikums Charité, Humboldt-Universität, Berlin, Germany.
Eur Arch Otorhinolaryngol. 1993;250(7):396-400. doi: 10.1007/BF00180384.
Changes in cochlear microcirculation and oxygenation and auditory function were examined in anesthetized guinea pigs during prolonged hypoxic ventilation (8% oxygen in nitrogen) for 1 h. Cochlear blood flow and perilymphatic oxygen partial pressure were measured using laser Doppler flowmetry and oxygen-sensitive microelectrodes. Auditory function was examined by recording cochlear microphonics, compound action potentials and auditory evoked brainstem response. Blood pressure and heart rate were monitored. During systemic hypoxia, the perilymphatic PO2 dropped on average to about 70% of the initial value. Cochlear and brainstem potentials showed a mean reduction to 75-82%. Different effects of hypoxia on cochlear blood flow were observed and included decreases as well as increases. Mean arterial blood pressure declined significantly during hypoxia, while the heart rate remained constant. The changed variables returned to normal during reventilation with room air. The findings are discussed with regard to their significance as an animal model for the study of hypoxia-induced cochlear pathophysiology.
在麻醉的豚鼠中，在持续1小时的低氧通气（氮气中8%氧气）期间，检查了耳蜗微循环、氧合和听觉功能。使用激光多普勒血流仪和氧敏感微电极测量耳蜗血流量和外淋巴氧分压。通过记录耳蜗微音器电位、复合动作电位和听觉诱发电位脑干反应来检查听觉功能。监测血压和心率。在全身性低氧期间，外淋巴PO2平均降至初始值的约70%。耳蜗和脑干电位平均降低至75 - 82%。观察到低氧对耳蜗血流量有不同影响，包括减少和增加。低氧期间平均动脉血压显著下降，而心率保持不变。在恢复室内空气通气期间，变化的变量恢复正常。讨论了这些发现作为研究低氧诱导的耳蜗病理生理学动物模型的意义。
