Bai Xue, Li Xu, Ma Jun, Guan Bai-Ou
Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications, Institute of Photonics Technology, Jinan University, Guangzhou, 511443, China.
Vis Comput Ind Biomed Art. 2021 Feb 23;4(1):4. doi: 10.1186/s42492-021-00070-4.
In this study, a virtual-point concept was introduced into fiber-laser photoacoustic tomography to improve the elevational image resolution. The flexible fiber laser was bent into an arc shape to conform to the ultrasound wavefront, which formed an ultrasound focus at the center of the arc. The synthetic aperture focusing technique was utilized to reconstruct the images; as a result, the elevational resolution particularly within the out-of-focus region was considerably improved compared to the resolution of an image retrieved by multiplexing the PA time-resolved signals with sound velocity. The all-optical fiber-laser photoacoustic tomography system with a high spatial resolution has potential for various applications, including biomedical research and preclinical/clinical diagnosis.
在本研究中，将虚拟点概念引入光纤激光光声断层扫描以提高仰角图像分辨率。将柔性光纤激光弯曲成弧形以符合超声波前向波，这在弧形中心形成了一个超声焦点。利用合成孔径聚焦技术重建图像；结果，与通过将光声时间分辨信号与声速复用检索到的图像分辨率相比，特别是在离焦区域内的仰角分辨率有了显著提高。具有高空间分辨率的全光纤激光光声断层扫描系统在包括生物医学研究和临床前/临床诊断在内的各种应用中具有潜力。
