大鼠大脑的19F 2-氟代脱氧葡萄糖核磁共振成像

19F 2-FDG NMR imaging of the brain in rat.

作者信息

Nakada T, Kwee I L, Griffey B V, Griffey R H

机构信息

Neurochemistry Research Laboratory, Veterans Administration Medical Center, Martinez, California 94553.

出版信息

Magn Reson Imaging. 1988 Nov-Dec;6(6):633-5. doi: 10.1016/0730-725x(88)90085-9.

DOI:10.1016/0730-725x(88)90085-9

PMID:3210906

Abstract

Images of the rat head reflecting glucose utilization were obtained using 2-fluoro-2-deoxy-D-glucose (2-FDG) and 19F nuclear magnetic resonance (NMR) imaging. Spatial heterogeneity of glucose utilization in the rat head was clearly demonstrated showing significantly higher glucose utilization in the brain as compared to the surrounding tissues. Although the potential adverse effects of the high doses of 2-FDG (400 mg/kg) needed to perform the study preclude immediate application of this technique to clinical quantitative glucose utilization studies, the present study shows potential for future development of glucose utilization imaging by NMR.

摘要

利用2-氟-2-脱氧-D-葡萄糖（2-FDG）和19F核磁共振（NMR）成像获得了反映大鼠头部葡萄糖利用情况的图像。大鼠头部葡萄糖利用的空间异质性得到了清晰展示，结果表明，与周围组织相比，大脑中的葡萄糖利用率显著更高。尽管开展该研究所需的高剂量2-FDG（400 mg/kg）可能存在潜在不良影响，使得该技术无法立即应用于临床定量葡萄糖利用研究，但本研究显示了NMR葡萄糖利用成像未来发展的潜力。