School of Public Health, Medical College of Soochow University, Suzhou, China.
Department of Mathematics, Statistics, and Computer Science, Macalester College, St. Paul, MN, USA.
Sleep Med. 2021 May;81:1-7. doi: 10.1016/j.sleep.2021.02.004. Epub 2021 Feb 8.
Our aim was to investigate the association between sleep and the development of metabolic syndrome (MetS) in Chinese older adults and to accumulate evidence for the prevention of MetS through sleep management.
This prospective study followed 3005 participants aged over 60 derived from the Weitang Geriatric Diseases Study who were without MetS at baseline. MetS was defined according to the Adult Treatment Panel III (ATP III) criteria. Logistic regression models were fit to assess the association between sleep and MetS incident and a linear regression model was used to examine the impact of sleep duration on every component of MetS. Data on sleep-related parameters were obtained based on a self-reported questionnaire.
After five-year follow-up, 13.51% participants developed MetS, of which 46.86% were women. The incidence of MetS was highest among adults who slept 6 h or less and lowest among those who slept 7 h after adjusted for multiple variables. Subgroup analyses showed no gender specificity. The variation of fasting plasma glucose (FBG) for ≥9 h per night was significantly lower than that for 7.01-7.99 h per night (β = -0.18, P < 0.05). Sleeping for 8-8.99 h also decreased the variation of diastolic blood pressure (DBP) compared to 7.01-7.99 h (β = -0.84, P < 0.05).
We conclude that both short and long sleep duration are risk factors for MetS incident in older adults.
本研究旨在探讨中国老年人睡眠与代谢综合征（MetS）发生的相关性，并为通过睡眠管理预防 MetS 提供依据。
本前瞻性研究共纳入了 3005 名年龄在 60 岁以上、基线时无 MetS 的来自卫塘老年疾病研究的参与者。MetS 按照成人治疗专家组 III（ATP III）标准定义。采用 logistic 回归模型评估睡眠与 MetS 发生的相关性，采用线性回归模型检验睡眠时间对 MetS 各组分的影响。睡眠相关参数的数据来源于一份自报告问卷。
经过 5 年的随访，13.51%的参与者发生了 MetS，其中 46.86%为女性。在调整了多个变量后，睡眠时间为 6 小时或更少的成年人发生 MetS 的比例最高，而睡眠时间为 7 小时的成年人发生 MetS 的比例最低。亚组分析显示，这种关联在性别上没有特异性。与每晚睡眠 7.01-7.99 小时相比，每晚睡眠≥9 小时的空腹血糖（FBG）变异显著降低（β=-0.18，P<0.05）。与每晚睡眠 7.01-7.99 小时相比，每晚睡眠 8-8.99 小时也可降低舒张压（DBP）的变异（β=-0.84，P<0.05）。
我们的结论是，无论是短睡眠还是长睡眠，都是老年人发生 MetS 的危险因素。
