Department of Environmental Engineering, College of Engineering, Ajou University, Suwon, South Korea.
Department of Biological Engineering, College of Engineering, Konkuk University, Seoul, Republic of Korea.
Crit Rev Biotechnol. 2021 Sep;41(6):827-848. doi: 10.1080/07388551.2021.1888069. Epub 2021 Feb 23.
is regarded as a suitable host for biochemical production owing to its excellent growth and bioresource utilization characteristics. In addition, the distinct endogenous metabolic pathways and the suitability of the heterologous pathways have made a robust and promising host for producing biochemicals, such as: bioalcohols; bioorganic acids (lactic acids, -ketoglutaric acid, and -aminobutyric acid); biopolymers (poly(-glutamic acid, polyhydroxyalkanoates (PHA), and polysaccharides and monosaccharides (N-acetylglucosamine, xylooligosaccharides, and hyaluronic acid)); and bioflocculants. Also for producing oligopeptides and functional peptides, owing to its efficient protein secretion system. Several metabolic and genetic engineering techniques, such as target gene overexpression and inactivation of bypass pathways, have led to the improvement in production titers and product selectivity. In this review article, recent progress in the utilization of robust -based host systems for biomass conversion and biochemical production has been highlighted, and the prospects of such host systems are suggested.
由于其出色的生长和生物资源利用特性，被视为生化生产的合适宿主。此外，独特的内源性代谢途径和异源途径的适用性，使成为生产生物化学物质的强大而有前途的宿主，如：生物醇；生物有机酸（乳酸、-酮戊二酸和-氨基丁酸）；生物聚合物（聚（谷氨酸）、聚羟基烷酸酯（PHA）和多糖和单糖（N-乙酰葡萄糖胺、木低聚糖和透明质酸）；和生物絮凝剂。由于其高效的蛋白质分泌系统，也可用于生产寡肽和功能性肽。几种代谢和遗传工程技术，如靶基因过表达和旁路途径的失活，导致生产滴度和产物选择性的提高。在这篇综述文章中，强调了利用稳健的基于宿主系统进行生物质转化和生化生产的最新进展，并提出了这种宿主系统的前景。
