College of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guian New Area 550025, P. R. China.
Shenzhen Institute for Drug Control, Shenzhen Testing Center of Medical Devices, Nanshan, Shenzhen 518057, P. R. China.
Am J Chin Med. 2021;49(2):359-389. doi: 10.1142/S0192415X21500178. Epub 2021 Feb 20.
Gagnep. (ST) (Fabaceae) is distributed chiefly in south-central and southeast China and Vietnam. In traditional Chinese medicine theory, the root and rhizome of ST are toxic and mainly used in the treatment of pharyngeal and laryngeal diseases. Modern studies provide new insights into the pharmacological and toxicological aspects of ST. The pharmacological and toxicological properties of ST were reviewed in this paper based on the literature from Google Scholar and CNKI, and the bioinformatics platforms were applied to explore the pharmacological and toxicological potentials of ST. The results of the literature analysis showed that ST has hepatoprotective, immunomodulatory, and anticancer effects and produces obvious toxicity to the liver and nervous and cardiovascular system. The results of bioinformatics showed that the compounds from ST may be applied to the treatment of cancer and digestive and nervous system diseases and show the possibility to cause hematotoxicity, neurotoxicity, and immunotoxicity. The present review demonstrates that attention should be paid to the potential toxicity of ST in the treatment of diseases and provides the reference for the subsequent pharmacological toxicological studies on the mechanism and chemical basis of ST.
葛藤（ST）（豆科）主要分布在中国中南部和东南部以及越南。在中医理论中，ST 的根和根茎有毒，主要用于治疗咽喉疾病。现代研究为 ST 的药理学和毒理学方面提供了新的见解。本文基于 Google Scholar 和 CNKI 的文献，综述了 ST 的药理学和毒理学特性，并应用生物信息学平台探讨了 ST 的药理学和毒理学潜力。文献分析结果表明，ST 具有保肝、免疫调节和抗癌作用，对肝脏以及神经和心血管系统有明显毒性。生物信息学结果表明，ST 中的化合物可能应用于治疗癌症和消化系统及神经系统疾病，并显示出引起血液毒性、神经毒性和免疫毒性的可能性。本综述表明，在治疗疾病时应注意 ST 的潜在毒性，并为后续 ST 的机制和化学基础的药理学毒理学研究提供参考。
