Ahanchi Noushin Sadat, Tamehri Zadeh Seyed Saeed, Khalili Davood, Azizi Fereidoun, Hadaegh Farzad
Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, No. 24, Parvaneh Street, Velenjak, Tehran, Iran.
School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
J Transl Med. 2021 Feb 23;19(1):84. doi: 10.1186/s12967-021-02749-x.
To identify sex specific trajectories of waist circumference (WC),triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C) and fasting plasma glucose (FPG) during adulthood and examine their associations with incident hypertension.
The cohort consisted of 5030 participants (2051 males) with at least 2 repeated measurement during a median of 12 years follow up. We identified trajectory groups using latent class growth mixture model, their association with hypertension was examined using multivariate Cox-regression analysis.
We found 997 cases of hypertension (483 male). For both exposures, three distinct trajectory groups were identified in both genders. For WC, in women: low-increasing, 82.4%; high-stable, 13.4%; high-increasing, 4.2% and in men: stable, 94.6%; low-increasing, 3.6% and for high- increasing, 1.7%. For TG, in women: stable, 91.3%; decreasing, 5.9%; inverse U-shape, 2.8%; in men: stable, 89.7%; inverse U- shape, 6.2% and for decreasing, 4.1%. Regarding WC, high stable and high-increasing trajectories were associated with hypertension in the multivariate model [(hazard ratio (HR) = 1.66 (95% CI 1.26-2.20) and 2.78(1.79-3.60), respectively]. Among men, this association was shown only for the low-increasing trajectory [2.76: 1.49-5.10]. For TG, among women decreasing and inverse U-shape trajectories were significantly associated with hypertension in the multivariate model [1.32:1.01-1.76] and [2.23:1.58-3.23, respectively]. We did not find any impact of increasing trajectories of FPG and HDL-C on incident hypertension. Considering TC, all individuals followed a stable trajectory.
WC dynamic changes in both gender and TG trajectory among women were significantly associated with incident hypertension.
确定成年期腰围（WC）、甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）和空腹血糖（FPG）的性别特异性轨迹，并研究它们与高血压发病的关联。
该队列由5030名参与者（2051名男性）组成，在中位随访12年期间至少进行了2次重复测量。我们使用潜在类别增长混合模型确定轨迹组，使用多变量Cox回归分析研究它们与高血压的关联。
我们发现997例高血压病例（483例男性）。对于这两种暴露因素，在两性中均确定了三个不同的轨迹组。对于腰围，女性中：低增长型，82.4%；高稳定型，13.4%；高增长型，4.2%；男性中：稳定型，94.6%；低增长型，3.6%；高增长型，1.7%。对于甘油三酯，女性中：稳定型，91.3%；下降型，5.9%；反U型，2.8%；男性中：稳定型，89.7%；反U型，6.2%；下降型，4.1%。关于腰围，在多变量模型中，高稳定型和高增长型轨迹与高血压相关[风险比（HR）分别为1.66（95%置信区间1.26 - 2.20）和2.78（1.79 - 3.60）]。在男性中，这种关联仅在低增长型轨迹中显示[2.76：1.49 - 5.10]。对于甘油三酯，在女性中，下降型和反U型轨迹在多变量模型中与高血压显著相关[分别为1.32：1.01 - 1.76]和[2.23：1.58 - 3.23]。我们未发现空腹血糖和高密度脂蛋白胆固醇的增长轨迹对高血压发病有任何影响。考虑到总胆固醇，所有个体均遵循稳定轨迹。
两性的腰围动态变化以及女性的甘油三酯轨迹与高血压发病显著相关。
