mRNA 中胞嘧啶-5 甲基化的新兴作用

The Emerging Roles of Cytosine-5 Methylation in mRNAs.

机构信息

Department of Biology and Biochemistry, Claverton Down, University of Bath, Bath, BA2 7AY, UK.

出版信息

Trends Genet. 2021 Jun;37(6):498-500. doi: 10.1016/j.tig.2021.02.001. Epub 2021 Feb 20.

DOI:10.1016/j.tig.2021.02.001

Abstract

Recent studies have unequivocally confirmed the presence of 5-methylcytosine (m5C) in mammalian mRNAs while indicating significant functional roles for this internal base modification type. Here, a brief history of m5C epitranscriptome research and a discussion of the important ways in which the field may now progress is presented.

摘要

最近的研究明确证实了 5-甲基胞嘧啶（m5C）在哺乳动物 mRNA 中的存在，同时表明这种内部碱基修饰类型具有重要的功能作用。本文简要介绍了 m5C 转录组外修饰的研究历史，并讨论了该领域目前可能取得重要进展的几种方式。