肠球菌的生理学和抗菌耐药性：街灯变得更亮了。
Enterococcal Physiology and Antimicrobial Resistance: The Streetlight Just Got a Little Brighter.
机构信息
Department of Medicine, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
出版信息
mBio. 2021 Feb 23;12(1):e03511-20. doi: 10.1128/mBio.03511-20.
differs from many other common human pathogens in its physiology and in its susceptibility to antimicrobial agents. Multiresistant strains owe their phenotypes to a combination of intrinsic and acquired antimicrobial resistance determinants. Acquired resistance is due to frequenting multicultural environments, its capacity to mate with different species, and the nullification of its own defense mechanisms in some lineages. Intrinsic resistance is a complex phenomenon that is intimately tied to the physiology of the species. In their recent study in , Gilmore and colleagues (M. S. Gilmore, R. Salamzade, E. Selleck, N. Bryan, et al., mBio 11:e02962-20, 2020, https://doi.org/10.1128/mBio.02962-20) use functional genomics to explore the genetic underpinnings of physiology and antimicrobial resistance. While they do not come up with many definitive answers, their work points the way toward new and fruitful areas of investigation.
它在生理学和对抗菌药物的敏感性方面与许多其他常见的人类病原体不同。多耐药菌株的表型归因于固有和获得性抗菌耐药决定因素的组合。获得性耐药是由于频繁接触多元文化环境、与不同物种交配的能力以及在某些谱系中消除自身防御机制的能力。固有耐药是一种与物种生理学密切相关的复杂现象。在他们最近的研究中（M. S. Gilmore、R. Salamzade、E. Selleck、N. Bryan 等人，mBio 11:e02962-20，2020，https://doi.org/10.1128/mBio.02962-20），吉尔摩和同事使用功能基因组学来探索生理学和抗菌药物耐药性的遗传基础。虽然他们没有得出很多明确的答案，但他们的工作为新的、富有成效的研究领域指明了方向。
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