Department of Thoracic and Cardiovascular Surgery, Nara Medical University School of Medicine, Nara, Japan;
Department of Surgery, Osaka Kaisei Hospital, Osaka, Japan.
In Vivo. 2021 Mar-Apr;35(2):1027-1031. doi: 10.21873/invivo.12346.
BACKGROUND/AIM: Transbronchial lung biopsy (TBLB) has been recommended for patients with suspected lung cancer. However, its diagnostic value is limited to small lesions, and some studies have indicated that biopsy might be related to metastasis and/or dissemination. This study aimed to evaluate the outcomes after preoperative TBLB for non-small cell lung cancer (NSCLC) patients.
Data were reviewed from 371 patients with resected pN0 NSCLC less than 3-cm. Patients were divided into two groups: TBLB and Non-TBLB. Recurrence-free survival (RFS) curves were plotted using the Kaplan-Meier method. Cox regression analyses were used to evaluate the hazard ratio (HR) with the endpoint RFS.
The 5-year RFS rates were 75.5% in the TBLB group and 91.4% in the Non-TBLB group (p<0.001). Poor RFS was independently associated with TBLB (HR=2.491, 95%CI=1.337-4.640; p=0.004).
Preoperative TBLB may adversely affect RFS among NSCLC patients with small size tumours.
背景/目的:经支气管肺活检(TBLB)已被推荐用于疑似肺癌患者。然而,其诊断价值仅限于小病变,一些研究表明活检可能与转移和/或播散有关。本研究旨在评估术前 TBLB 对非小细胞肺癌(NSCLC)患者的预后影响。
回顾性分析了 371 例小于 3cm 的 pN0 NSCLC 患者的资料。患者分为 TBLB 组和非 TBLB 组。采用 Kaplan-Meier 法绘制无复发生存(RFS)曲线。采用 Cox 回归分析评估以 RFS 为终点的风险比(HR)。
TBLB 组的 5 年 RFS 率为 75.5%,非 TBLB 组为 91.4%(p<0.001)。较差的 RFS 与 TBLB 独立相关(HR=2.491,95%CI=1.337-4.640;p=0.004)。
术前 TBLB 可能会对小肿瘤大小的 NSCLC 患者的 RFS 产生不利影响。