经支气管活检对手术切除的非小细胞肺癌的临床意义
Clinical Implications of Transbronchial Biopsy for Surgically-resected Non-small Cell Lung Cancer.
作者信息
Yasukawa Motoaki, Sawabata Noriyoshi, Kawaguchi Takeshi, Kawai Norikazu, Taniguchi Shigeki
机构信息
Department of Thoracic and Cardiovascular Surgery, Nara Medical University School of Medicine, Nara, Japan
Department of Thoracic and Cardiovascular Surgery, Nara Medical University School of Medicine, Nara, Japan.
出版信息
In Vivo. 2018 May-Jun;32(3):691-698. doi: 10.21873/invivo.11295.
BACKGROUND/AIM: Lung biopsies might cause metastasis and/or dissemination. The aim of this study was to review our institutional experience and analyze the outcomes of resection for non-small cell lung cancer (NSCLC), in patients who had received preoperative transbronchial biopsy using fiberoptic bronchoscopy with fluoroscopic imaging (BFS).
PATIENTS AND METHODS
The medical records of consecutive patients between 2010 and 2015 were retrospectively reviewed. Patients were divided into two groups (BFS and Non-BFS). Overall survival (OS) curves and recurrence-free survival (RFS) curves were plotted using the Kaplan-Meier method. Cox regression analyses were used to evaluate the hazard ratio (HR) with the endpoint OS or RFS.
RESULTS
We studied the medical records of 531 patients. The 5-year OS rate was 91.8% and 79.8%, in the BFS group and in the Non-BFS group, respectively (p<0.001). BFS was an independent factor associated with RFS HR=2.164 (95%CI=1.399-2.346).
CONCLUSION
Preoperative BFS is a prognostic factor in patients receiving surgery for NSCLC.
背景/目的：肺活检可能导致转移和/或播散。本研究的目的是回顾我们机构的经验，并分析接受术前经纤维支气管镜荧光透视活检（BFS）的非小细胞肺癌（NSCLC）患者的手术切除结果。
患者与方法
回顾性分析2010年至2015年间连续患者的病历。患者分为两组（BFS组和非BFS组）。采用Kaplan-Meier法绘制总生存（OS）曲线和无复发生存（RFS）曲线。采用Cox回归分析评估以OS或RFS为终点的风险比（HR）。
结果
我们研究了531例患者的病历。BFS组和非BFS组的5年总生存率分别为91.8%和79.8%（p<0.001）。BFS是与RFS相关的独立因素，HR=2.164（95%CI=1.399-2.346）。
结论
术前BFS是接受NSCLC手术患者的一个预后因素。
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