Otunla Afolarin A, Bradley Kevin M
Medical Sciences Division, University of Oxford, Oxford, United Kingdom.
Wales Research and Diagnostic PET Imaging Centre, University of Cardiff, Oxford, United Kingdom.
World J Nucl Med. 2020 Oct 27;19(4):452-454. doi: 10.4103/wjnm.WJNM_76_20. eCollection 2020 Oct-Dec.
Pilomatricoma, also known as calcifying epithelioma of Malherbe, is a rare skin tumor originating from the hair follicle matrix. We report a case of pilomatricoma in a 50-year-old woman, presenting as a rapidly growing pretibial mass. Malignant pilomatricoma is associated with potentially fatal metastases and are clinically and histologically indistinguishable from benign pilomatricoma. Thus, an F-fluorodeoxyglucose positron emission tomography-computed tomography (F-FDG PET/CT) scan was requested for staging, revealing marked FDG uptake restricted to the primary lesion and no evidence of separate disease. The purpose of this report is to demonstrate the importance of PET/CT in the staging of this FDG-avid tumor; the malignancy of which is often first revealed by metastases. Our case also demonstrates that pilomatricoma should be included in the differential diagnosis of a rapidly growing peripheral soft-tissue mass; conventionally, the domain of sarcoma.
毛发瘤，也称为马尔赫布钙化上皮瘤，是一种起源于毛囊基质的罕见皮肤肿瘤。我们报告一例50岁女性的毛发瘤病例，表现为胫前迅速生长的肿块。恶性毛发瘤可发生潜在致命的转移，在临床和组织学上与良性毛发瘤无法区分。因此，我们进行了一次氟脱氧葡萄糖正电子发射断层扫描-计算机断层扫描（F-FDG PET/CT）检查以进行分期，结果显示FDG摄取明显局限于原发病变，未发现其他病变迹象。本报告的目的是证明PET/CT在这种FDG摄取阳性肿瘤分期中的重要性；其恶性程度通常首先通过转移表现出来。我们的病例还表明，毛发瘤应纳入迅速生长的外周软组织肿块的鉴别诊断中；传统上，这是肉瘤的范畴。
