Pai Trupti, Harwani Shweta R, Patil Asawari, Sahay Ayushi, Shet Tanuja, Parmar Vani, Wadasadawala Tabassum, Desai Sangeeta B
Department of Pathology, Tata Memorial Centre, Mumbai, Maharashtra, India.
Department of Surgical, Tata Memorial Centre, Mumbai, Maharashtra, India.
Indian J Med Paediatr Oncol. 2017 Jul-Sep;38(3):367-370. doi: 10.4103/ijmpo.ijmpo_118_16.
Pilomatrix carcinoma is an exceedingly rare skin adnexal neoplasm derived from piliferous follicles, usually occurring in the head and neck region. Localization of this tumor in the breast is a rarity. We now report an unusual case of a 49-year-old female who presented with a palpable mass in the left breast for 2 years. Mammogram revealed a large, lobulated opacity with calcification, and positron emission tomography-computed tomography showed a metabolically active soft tissue mass measuring 15 cm involving all the quadrants of the left breast. Subsequently, the patient underwent radical mastectomy, and histopathologic diagnosis of pilomatrix carcinoma of the breast was offered. Pilomatrix carcinoma, although exceedingly rare, can have an intramammary location and can be misdiagnosed as breast carcinoma on limited material. A high index of suspicion is required to arrive at an accurate diagnosis so as to obviate neoadjuvant chemotherapy.
毛母质癌是一种极其罕见的皮肤附属器肿瘤，起源于毛囊，通常发生在头颈部区域。该肿瘤发生于乳腺极为罕见。我们现报告一例不寻常病例，一名49岁女性，左乳可触及肿块2年。乳房X线摄影显示一个伴有钙化的大的分叶状不透光区，正电子发射断层扫描-计算机断层扫描显示一个代谢活跃的软组织肿块，大小为15 cm，累及左乳所有象限。随后，患者接受了根治性乳房切除术，术后病理诊断为乳腺毛母质癌。毛母质癌虽然极为罕见，但可发生于乳腺内，在取材有限的情况下可能被误诊为乳腺癌。需要高度怀疑才能做出准确诊断，从而避免新辅助化疗。
