肾功能不全中的致癌机制。

Volovat Simona Ruxandra, Volovat Constantin, Miron Ingrith, Kanbay Mehmet, Goldsmith David, Lungulescu Cristian, Badarau Silvia Corina, Covic Adrian

Department of Medical Oncology, University of Medicine and Pharmacy 'Grigore T Popa', Iasi, Romania.

Department of Nephrology, Division of Nephrology, Department of Medicine, Koc University School of Medicine, Istanbul, Turkey.

Clin Kidney J. 2020 Oct 23;14(2):507-515. doi: 10.1093/ckj/sfaa122. eCollection 2021 Feb.

The prevalence of both cancer and end-stage renal disease is increasing. In addition, medical advances have meant increased survival rates for both diseases. Many chemotherapeutics are renally excreted, and conversely, renal insufficiency promotes a pro-neoplastic state, including genitourinary and other cancers. Dialysis prolongs life while increasing cancer risk. Proposed oncogenic mechanisms include immune dysfunction, chronic inflammation, changes in gut microbiota and stimulation of the renin-angiotensin system. This review summarizes current concepts in the relationship between cancer and renal insufficiency.

癌症和终末期肾病的患病率都在上升。此外，医学进步意味着这两种疾病的生存率都有所提高。许多化疗药物经肾脏排泄，反之，肾功能不全可促进肿瘤发生状态，包括泌尿生殖系统及其他癌症。透析延长了生命，但同时增加了患癌风险。推测的致癌机制包括免疫功能障碍、慢性炎症、肠道微生物群变化以及肾素 - 血管紧张素系统的刺激。本综述总结了癌症与肾功能不全之间关系的当前概念。